Includes detailed notes on the following lectures:
Lecture 6: Principles of drug action on neurotransmission
Lecture 7: Neurotransmitter identification and proof of function
Lecture 8: Drugs affecting neuromuscular transmission
Lecture 9: Drugs affecting the parasympathetic nervous system
Le...
Fundamentals of Drug
Modification on
Neurotransmission, Receptors in
the ANS
, LECTURE 6:
Neurotransmission and how neurotransmission may be modified by
drugs.
Neurotransmitters to know:
Noradrenaline (NA) - sympathetic
terminals
Acetylcholine (ACh) - parasympathetic
terminals, ganglia and Neuromuscular
junctions (NMJ)
Dopamine (DA) - parts of the CNS
Serotonin (5-HT) - parts of the CNS
Nitric Oxide (NO) - odd places like
endothelium
Ganglia: a group or tissue with high
concentrations of neurons.
Sympathetic Nervous system: Emanates from Thoracolumbar segments of spinal
cord. Ganglions typically close to the spinal cord in the paravertebral chain.
Areas of drug modification on neurotransmitter
Synthesis / Storage of NT
1. Stimulatory effects
a. Provide excess precursor (L-DOPA)
2. Inhibitory effects
a. Block precursor uptake
(hemicholinium)
b. Enzyme cascade (AMPT)
c. Storage (Reserphine)
Release of NT
3. Stimulation
a. Displaces NT
(amphetamine)
4. Inhibition
a. Depolarization (guanethide)
b. Ca uptake (conotoxin)
c. Vesicle fusion (botulinum)
d. Presynaptic receptor
(clodine)
Termination of neurotransmission
5. Inhibition, (will have stimulatory
effect)
a. Reuptake (cocaine)
b. Inhibit enzymatic
degradation (neostigmine)
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