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Summary Wk2Assgn.NURS6521C.doc NURS 6521 Pharmacotherapy for Cardiovascular Disorders Case Study Master of Science in Nursing, Walden University NURS 6521: Advanced Pharmacology Pharmacotherapy for Cardiovascular Disorders Case Study The purpose of this cas
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Wk2Assgn.NURS6521C.doc NURS 6521 Pharmacotherapy for Cardiovascular Disorders Case Study Master of Science in Nursing, Walden University NURS 6521: Advanced Pharmacology Pharmacotherapy for Cardiovascular Disorders Case Study The purpose of this case study is to address how age can influence ...
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NURS 6521
Pharmacotherapy for Cardiovascular Disorders Case Study
Master of Science in Nursing, Walden University
NURS 6521: Advanced Pharmacology
Pharmacotherapy for Cardiovascular Disorders Case Study
The purpose of this case study is to address how age can influence pharmacokinetic and
pharmacodynamic processes. The case study presented is “Patient AO has a history of obesity
and has recently gained 9 pounds. The patient has been diagnosed with hypertension and
hyperlipidemia. Drugs currently prescribed include atenolol 12.5mg daily, doxazosin 8mg daily,
hydralazine 10mg QID, sertraline 25mg daily and simvastatin 80mg daily.” Implications of age-
related changes in relation to drug therapy processes are explored. Lastly, recommendations for
improving AO’s drug therapy plan are made with an explanation of recommendations.
Age Affecting Pharmacokinetics and Pharmacodynamics
Age is a significant factor that has the potential to influence AO’s pharmacokinetic and
pharmacodynamic processes with drug therapy. Pharmacokinetics studies the basic processes of
absorption, distribution, metabolism, and excretion while pharmacodynamics studies the effects
that drugs have on the body (Rosenthal & Burchum, 2021). In the aging body there are changes
in all the pharmacokinetic processes. Decreases in small-bowel surface area and slowed gastric
emptying can affect absorption (Ruscin & Linnebur, 2018). Distribution can be affected in the
aging malnourished patient when there is a decrease in serum albumin. With this decrease of
protein, the drug effects are enhanced because there are higher concentrations that are not bound
to albumin which can cause toxic levels (Ruscin & Linnebur, 2018).
Unfortunately, pharmacodynamics does not have as much data to support age related
changes. According to Sera and Uritsky (2016) “differences in pharmacodynamics between
young and older adults may be due partly to age-related changes and partly to changes in
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