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Test Bank for Molecular Biology of the Cell 6th Edition by Bruce Alberts.
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Test Bank for Molecular Biology of the Cell 6th Edition byBruce Alberts
,MOLECULAR BIOLOGY OF THE CELL, SIXTH EDITION
CHAPTER 3: PROTEINS
1.At physiological pH, what is the approximate net charge of a hexapeptide with the following
amino acid sequence?
Asp-Val-Ile-Glu-Arg-Ser
A. –2
B. –1
C. 0
D. +1
E. +2
2.Which of the following pairs of amino acid residues would you expect to form ionic bonds?
A. Glutamic acid and glutamine
B. Arginine and lysine
C. Lysine and glutamic acid
D. Tryptophan and tyrosine
E. Tyrosine and glutamine
3.Which of the following stretches of amino acid residues would you expect to find in the
interior of protein molecules?
A. Ala-Asp-Asp-Tyr-Arg B.
Gly-Lys-Ser-Pro-Thr
C. Phe-Glu-Gln-Glu-Asn
D. Ala-Val-Leu-Ile-Trp
E. Gly-Tyr-His-Arg-His
, 4.Which of the following is NOT the role of molecular chaperones in the folding of cellular
proteins?
A. They assist proteins in folding into their correct conformations.
B. They help prevent formation of protein aggregates.
C. They specify the final three-dimensional shape of proteins.
D. They catalyze the folding of proteins in the crowded environment of the cell.
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E. They make the protein-folding process in the cell more reliable.
5.The observation that proteins often renature into their original conformations after they have
been unfolded by denaturing solvents implies that …
A. the information needed to specify the three-dimensional shape of a protein is encoded
in its amino acid sequence.
B. the cell does not need molecular chaperones for survival.
C. the final folded structure of a protein is usually NOT the one with the lowest free
energy.
D. each protein folds into several different conformations inside the cell.
E. All of the above.
6. Imagine a cellular protein composed of 3000 amino acid residues in one continuous
polypeptide chain. This protein is almost certainly … A. extracellular.
B. globular.
C. multidomain.
D. composed of mostly α-helical regions.
E. intrinsically disordered.
7. For each of the following cartoon representations from left to right, indicate whether the
protein structure is composed of only α helices (1), only parallel β sheets (2), only
antiparallel β sheets (3), α helices plus parallel β sheets (4), or α helices plus antiparallel β
sheets (5) as repetitive secondary structure elements. Your answer would be a four-digit
number composed of digits 1 to 5 only, e.g. 5513.
Images created in PyMOL, from PDB entries 1STU, 2LPC, 1SA8, and 3BOB.
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