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Lecture notes Endocrinology Repoductive Endocrinology (BI2BB4) £7.99   Add to cart

Lecture notes

Lecture notes Endocrinology Repoductive Endocrinology (BI2BB4)

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The forth lecture in a series for the module Endocrinology. This lecture covers the basics of repoductive endocrinology, gametogensis, dimorphism, sex disorders and more. A great way to start your understanding of the module or to miss a lecture or two.

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  • August 7, 2022
  • 4
  • 2019/2020
  • Lecture notes
  • Dr phil knight
  • All classes
All documents for this subject (8)
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robbieseal
25.10.19


L4 – Reproductive endocrinology
Keywords:
Gametogenesis (formation of gametes), spermiogenesis (formation of sperm), oogenesis (formation
of eggs), dimorphism (physical difference between male and female), dysgenesis (abnormal organ
development) androgen (group of hormones that produce male traits)

Lecture:
 Sex determination THEN sex differentiation
 Depends on if spermatozoon contains X or Y chromosome
 Week 7 differentiates males and females (via sex-determining region of Y (SRY and SOX9
proteins formed))
 Undifferentiated genitalia contain Müllerian ducts and Wolffian ducts
o When differentiated in females Wolffian is lost
o When differentiated in males Müllerian is lost
 Not required ducts eg female ducts in a male regress caused by AMH hormone and high
androgen levels (opposite in females)

MALE REPODUCTIVE

 Seminal tubules = highly coiled tubules drain into rete
testis
o Fluid in lumen of tubules
o Interstitial tissue have Sertoli cells (nurse sperm
cells)
o Germ cells end up as spermatozoon
 Then drain into epididymis and sperm joined to urethra via
vas deferens
o Outside tubule = Leydig cells
 Hypothalamic-pit reg of LH and FSH (gonadotrophins)
o Synthesized by gonadotrophs in ant pit
o Stimulated by gonadotrophin releasing hormone
(GnRH)
o LH and FSH work on
 LH → Leydig cells = testosterone look more
active
 Testosterone also suppress GnRH
secretion by suppressing
hypothalamus
 Testosterone inhibits LH/FSH via
inhib alt pit
 FSH → Sertoli cells = inhibin
 Made of two proteins
 Inhibits FSH from pit
 Male hormones (androgens) required to make sperm
o All bind to androgen-binding protein
o Main androgen = testosterone
 Metabolized into dihydrotestosterone (potent)

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