Brief overview of fundamentals of genetic disorders, including recap on DNA replication, structural and numerical chromosomal abnormalities and how they arise
-Primase constructs a
primer ofRNAcomplementary to template,
which gives polymerase something bind to
DNA to
DNA
Polymerase adds nucleotides
direction
to exposed bases
in a
semi
↳ Easily done in one go for leading stand
↳
lagging strand is the other way so is
in small sections which then
formed are
joined
DNA
polymerase also PROOF-READS for errors
↳ Forms backbone on own
↳ Fragments oflagging side joined together by
DNA
ligase
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