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Summary Basics of Genetic Disorders £4.99   Add to cart

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Summary Basics of Genetic Disorders

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Brief overview of fundamentals of genetic disorders, including recap on DNA replication, structural and numerical chromosomal abnormalities and how they arise

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  • July 14, 2023
  • 4
  • 2021/2022
  • Summary
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jacklowe
Intro to Genetic Disorders
Firstly need a solid
grasp of miniosis
the



Replication
DNA
bits
key to understand:


-Replication is semi conservative -

Each strand is a
template
strand
I each daughter has
halforiginal
& other Enz.
Done
by DNA
Polymerases
-




There is a
leading stand s lagging strand due to
51+ 3' direction
replication in




process:
the

Helicase breaks H-bonds
-DNA bowl
bases separates
-
I strands

↳ stands coated w/
single-strand binding proteins
strands
rejoining early
-



to
stop

-Primase constructs a
primer ofRNAcomplementary to template,
which gives polymerase something bind to
DNA to




DNA
Polymerase adds nucleotides
direction
to exposed bases
in a
semi
↳ Easily done in one go for leading stand

lagging strand is the other way so is
in small sections which then
formed are

joined
DNA
polymerase also PROOF-READS for errors


↳ Forms backbone on own

↳ Fragments oflagging side joined together by
DNA
ligase

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