Lecture notes
Ligand protein binding lecture
- Module
- (BIOL1021)
- Institution
- University Of Southampton (UOS)
BSc Biomedical Sciences at University of Southampton Behaviour of biomolecules - Ligand protein binding lecture notes
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BIOL1021Syma Khalid
Office: B27/3037
S.Khalid@soton.ac.uk
, Recap of previous lectures
• Thermodynamics: basics
• Chemical potential
• Ideal gases & partial pressures
This lecture:
• Thermodynamics of ligand binding
to proteins
• Ideal solutions
, Ligand-protein binding
• Thermodynamics helps us to understand the biophysics of ligands
binding to proteins.
• For a simple case of one ligand, L binding to a protein, P:
K
P+L PL
• The equilibrium constant, K, for this reaction is given by:
[PL]
K = [P][L]
• However it is standard for biochemists to refer to a dissociation
constant, Kd which is:
Kd [P][L]
PL P+L therefore Kd = [PL] = 1/K
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