100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Rush - Advanced Pharmacology - NSG 531 - Exam 4 Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution £6.35
Add to cart
Quickly navigate to
Preview
  2.  
  3. NSG 531
  4.  
  5. NSG 531
  6.  
  7. NSG 531

Exam (elaborations)

Rush - Advanced Pharmacology - NSG 531 - Exam 4 Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

 0 purchase

Rush - Advanced Pharmacology - NSG 531 - Exam 4 Questions with 100% Actual correct answers | verified | latest update | Graded A+ | Already Passed | Complete Solution

Preview 2 out of 8  pages

Document information

  • June 17, 2024
  • 8
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers

Subjects

  • rush advanced pharmacology nsg 531 exam 4 qu

Written for

All documents for this subject (41)

Seller

avatar-seller
DoctorHkane

Reviews received

Content preview

Rush - Advanced Pharmacology - NSG
531 - Exam 4
30s unit - correct answer-samller unit that reads the codons and makes sure that the
bacteria gets the correct tRNA bound to it

50s unit - correct answer-catalyzes the formation of the peptide bonds between the amino
acids

acyclovir MOA - correct answer-has to be phosphorylated to work against viruses
the HSV has a specific kinase that will convert it into acyclovir phosphate then triphosphate
that is the active drug
so it is not active unless in the presence of herpes

Amantidine MOA - correct answer-binds M2 surface protein on influenza A, blocking
uncoating of viral RNA
either inhibits M2 protein or sits in the channel
doesn't allow hydrogen ion in to cause the release of genetic material

aminoglycoside AEs - correct answer-ototoxicity
renal failure
neuromuscular blockade

aminoglycosides - correct answer-bind to 30s subunit and induce mRNA misreading
largely used for gram negative bacteria
act synergistically with beta-lactams because beta lactams inhibit cell wall synthesis which
facilitates the entry of ahminoglycosides into the bacteria

aminoglycosides and the neuromuscular blockade - correct answer-can bind to calcium
channels on the surface of presynaptic neurons and block them
can act as calcium channel blockers in motor neurons which leads to a blockade because
there is no release of Ach from influx of calcium
in most extreme forms can have paralysis

Antibiotic resistance in inhibitors of polymer cross-linking - correct answer-could be related to
reduced affinity for bacterial transpeptidase or plasmids that encode for beta lactamase -
there is a genetic mutation that alters the shape of the transpeptidase so that the drug
doesn't bind to it as well
mutations can alter ability of drug to bind to bacterial transpeptidase and reduce its
effectiveness
plasmids can encode for beta lactamase which cleaves the beta lactam

arginine - correct answer-Arginine is used for treatment of heart and blood vessel conditions
including congestive heart failure (CHF), chest pain, high blood pressure, and coronary
artery disease.

, Don't use if:
excess body acid
high levels of potassium in the blood
sickle cell anemia
heart attack within the last 30 days
renal tubular acidosis
decreased kidney function
Don't use with nitro

bacterial resistance - correct answer-ability of bacteria to resist the action of antibiotics
bacteria replicate very fast, mutations are seen in a much shorter period of time
you can get mutations that will increase the number of efflux pumps that will pump the drug
out
bacterial membrane proteins need to be porous for the drug to get through - nonporous are
the ones that will survive antibiotics and replicate
when you add a selective pressure such as an antibiotic any bacteria that has a genetic
mutation is the kind that will grow out

Beta-lactamase inhibitors - correct answer-augmentin, unasyn, zosyn

these are combo drugs that try to overcome the genes in the bacteria that code for the beta
lactamase that will keep the drug from binding to the receptor to inhibit cross linking

biological basis of drug/herb/nutrient interactions - correct answer-absorption (changing pH
or motility of the GI tract)

Distribution (displacing agents that are bound to plasma proteins

Biotransformation (inducing or inhibiting CYP450 enzymes)

receptor binding (competitive and noncompetitive antagonism

chemotherapeutics: alkylating agents - correct answer-Bind to DNA

binds to DNA at the alkyl group between two guanines that would have gotten cross linked
if they can't cross link you are disrupting DNA and inserting something that shouldn't be
there

non-cell cycle specific - it damages DNA

must be oxidized by p450 to be activated

chemotherapeutics: antemetabolites - correct answer-inhibit DNA synthesis enzymes

works in the s phase

5FU binds to tymidylase synthase

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller DoctorHkane. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £6.35. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

65646 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 15 years now

Start selling

Recently viewed by you

Exam (elaborations) ·

(0)

Test Bank for Huether and McCances Understanding Pathophysiology Canadian Edition, 2nd Edition by Power-Kean, 9780323778848, Covering Chapters 1-42 | Includes Rationales

Exam (elaborations) ·

(0)

ATI RN Leadership Management Proctored Exam (5 Versions) (NGN, Latest-2023)/ RN ATI Leadership Management Proctored Exam / RN Leadership Management ATI Proctored Exam
£6.35
  • (0)
Add to cart
Added