ASCP Hematology Review
>20% defines what type of leukemia? - CORRECT ANSWER-acute
4 deleted alpha genes can result in the development of? - CORRECT
ANSWER-hydrops fetalis, nonviable fetus
A cold agglutinin screen determines? - CORRECT ANSWER-the presence of a
cold autoantibody
A falsely decreased ESR can be attributed to? - CORRECT ANSWER-QNS
specimen, decreased temperature
A falsely elevated ESR can be attributed to? - CORRECT ANSWER-tilting tube,
standing too long, increased temperature, excess EDTA
A G6PD deficiency is characterized by what lab findings? - CORRECT
ANSWER-decreased G6PD, heinz bodies
A heinz body prep can indicate what conditions? - CORRECT ANSWER-G6PD
deficiency, unstable hemoglobins, HbH
A kleihauer-betke acid elution measures? - CORRECT ANSWER-the resistance
of fetal hemoglobin to acid elution
A left shift in the hemoglobin-oxygen dissociation curve causes what changes in
the following substances: CO2, pH, 2,3-DPG? - CORRECT ANSWER-increased
pH, decreased CO2, decreased 2,3-DPG
A normal schilling test with IF indicates what type of problem or anemia? -
CORRECT ANSWER-pernicious anemia
A PK deficiency is characterized by what lab findings? - CORRECT
ANSWER-decreased PK, no heinz bodies
A positive Ham's test and a positive sucrose hemolysis test helps to diagnose
what condition - CORRECT ANSWER-PNH
,A reticulocyte production < 2 indicates? - CORRECT ANSWER-inadequate bone
marrow response to anemia
A reticulocyte production > 2 indicates? - CORRECT ANSWER-adequate bone
marrow response to anemia
A right shift in the hemoglobin-oxygen dissociation curve causes what changes in
the following substances: CO2, pH, 2,3-DPG? - CORRECT ANSWER-decreased
pH, increased CO2, increased 2,3-DPG
A sickle cell screen measures? - CORRECT ANSWER-the reduced solubility of
deoxygenated hemoglobin S
A t(15;17) genetic aberration is associated with what condition? - CORRECT
ANSWER-M3 AML
A t(8;21) genetic aberration is associated with what condition? - CORRECT
ANSWER-M3 AML
A t(9:22) Philadelphia chromosome is associated with what condition? -
CORRECT ANSWER-CML
A WBC differential is performed on a bone marrow in order to do what? -
CORRECT ANSWER-determine the type of leukemia present if diagnosed
Acanthocytes are commonly seen in what condition(s)? - CORRECT
ANSWER-severe liver disease, abetalipoproteinemia
Alder-Reilly is an anomaly which is characterized by? - CORRECT
ANSWER-large azurophilic granules (due to the increased presence of
mucopolysaccharides)
All non-embryonic hemoglobin types are comprised of what type of globin chain?
- CORRECT ANSWER-alpha
, An 11q/23 genetic aberration is associated with what condition? - CORRECT
ANSWER-M5 AML
An abnormal schilling test with or without IF indicates what type of problem or
anemia? - CORRECT ANSWER-malabsorption problem
An increase in hemoglobin F can cause what kind of shift in the
hemoglobin-oxygen dissociation curve? - CORRECT ANSWER-left shift
An increase in liver enzymes, target cells, and round macrocytes can indicate
what conditions/problems? - CORRECT ANSWER-liver disease, alcholism
An increase in the ESR value is see in conditions involving? - CORRECT
ANSWER-the presence of abnormal plasma proteins (inflammatory conditions)
An increased MCV with MCHC and decreased RBC is associated with what
condition? - CORRECT ANSWER-cold agglutinin disease
Another name for helmet cells is? - CORRECT ANSWER-keratocyte
Another word for sickle cells is? - CORRECT ANSWER-drepanocyte
Anti-malarial drugs and fava beans can exacerbate what condition? - CORRECT
ANSWER-G6PD deficiency
Are Dohle bodies present in a leukemoid reaction or CML? - CORRECT
ANSWER-leukemoid reaction
Auer rods are diagnostic for what condition? - CORRECT ANSWER-AML
Basophil counts are increased in what conditions? - CORRECT
ANSWER-immediate hypersensitivies
Bone marrow biopsies are performed to in order to evaulate what? - CORRECT
ANSWER-overall cellularity of the bone marrow
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