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Arrhythmic risk in young women with mitral valve prolapse: keep your eyes open but don’t jump at every shadow Katja Zeppenfeld * and Marta de Riva£6.35
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European Heart Journal (2024) 00, 1–3 EDITORIAL
https://doi.org/10.1093/eurheartj/ehae246 Arrhythmias
Arrhythmic risk in young women with mitral
valve prolapse: keep your eyes open but don’t
Downloaded from https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae246/7671162 by guest on 19 May 2024
jump at every shadow
Katja Zeppenfeld * and Marta de Riva
Department of Cardiology, Willem Einthoven Center for Cardiac Arrhythmia Research and Management, Leiden University Medical Center, C5-P, PO Box 9600, 2300 RC Leiden, the Netherlands
This editorial refers to ‘Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum’, by A. Sabbag et al.,
https://doi.org/10.1093/eurheartj/ehae224.
Graphical Abstract
Arrhythmic risk in pregnant women with mitral valve prolapse
On drugs
Rennes 1
Viet
OSL 4
UTR 3
SMC 2
Rennes 2
Mayo 1 On
UTR 2 Arrhythmic β-blocker
IKEM 1 mitral
SMCZ valve
OSL 169 prolapse
diagnosis Add
PSL8 Flecainide
SMC 1 (x4) (x4)
PSL 1
STOC On
PSL 3 Flecainide
2–3% prevalence MVP Mayo 2
All-cause maternal cardiac mortality BOY
≈ 0.0014%
Observational period
1x VT/VF perinatal period 1x VT/VF out of perinatal period
Left panel: Mitral valve prolapse is frequent in the general population, but SCD as one cause of cardiac mortality related to MVP during the perinatal
period is very rare. Right panel: Each of the 18 women included in the study is represented in one line. In the first column, an alphanumeric code indicates
the institution which has included the patient. The majority of women presented with an out-of-hospital cardiac arrest while not taking anti-arrhythmic
drugs, half of them during the perinatal period. Following the first episode, all were prescribed anti-arrhythmic drugs. Recurrences while on beta-
blockers were very sporadic and mainly occurred outside the perinatal period. Of note, VT/VF recurrence occurred in only one of eight patients while
on flecainide. Abbreviations: MVP, mitral valve prolapse; SCD, sudden cardiac death; VT, ventricular tachycardia; VF, ventricular fibrillation
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