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NSG 533 Exam 2 | Questions & Answers (100 %Score) Latest Updated 2024/2025 Comprehensive Questions A+ Graded Answers | With Expert Solutions £10.93   Add to cart

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NSG 533 Exam 2 | Questions & Answers (100 %Score) Latest Updated 2024/2025 Comprehensive Questions A+ Graded Answers | With Expert Solutions

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NSG 533 Exam 2 | Questions & Answers (100 %Score) Latest Updated 2024/2025 Comprehensive Questions A+ Graded Answers | With Expert Solutions

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  • August 7, 2024
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  • NSG 533
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NSG 533 Exam 2 | Questions & Answers (100 %Score) Latest Updated 2024/2025
Comprehensive Questions A+ Graded Answers | With Expert Solutions




genetics - study of inherited traits and their variation (individual)

genome - total genetic composition of an organism or species (group)

genomics - molecular analysis of the entire genome of a species

gene - basic unit of heredity

list the four types of mendelian inheritance - 1. autosomal dominant
2. autosomal recessive
3. X-linked dominant
4. X-linked recessive

autosomal dominant - - phenotype is expressed in those who have 1 copy of a gene
mutation

- mothers and fathers are equally likely to transmit or inherit the disorder

- seen in multiple generations

autosomal recessive - - requires presence of 2 copies of a gene mutation in order to
express phenotype

- usually seen in a single generation

- mothers/fathers equally likely to transmit or inherit disorder

X-linked dominant - - dominant disorder caused by a mutation in a gene on the X
chromosome

- heterozygous female (XAXa) and hemizygous male (XAY)

- affected males have more severe phenotype

X-Linked Recessive - mutation on gene in X chromosome causes phenotype to be
expressed in hemizygous males (XaY) and homozygous females (XaXa)

types of X-linked recessive disorders - 1. duchene muscular dystrophy
2. hemophilia
3. color blindness

, examples of X-Linked dominant disorders - 1. Fragile X syndrome
2. Rett syndrome

examples of Autosomal Dominant disorders - -Marfan syndrome
-Huntington disease

examples of Autosomal Recessive disorders - - cystic fibrosis
- sickle cell anemia
- PKU
- Tay-Sachs

types of genetic inheritance - 1. mendelian inheritance
2. non-mendelian inheritance

types of non-mendelian inheritance - 1. mitochondrial inheritance
2. genomic imprinting
3. uniparental disomy

mitochondrial inheritance - only females will transmit disease to their offspring

- the ova contains mitochondria, sperm does not

genomic imprinting - - gene from mother or father may be imprinted (silenced)

- if allele from mother is imprinted, only allele from father will be expressed

examples of genomic imprinting - 1. Prader-Willi Syndrome (paternal inheritance of
deletion)

2. angelman syndrome (maternal inheritance of deletion)

uniparental disomy - Offspring receives 2 copies of a chromosome from 1 parent and no
copies from the other parent.

types of chromosomal mutations (5) - 1. deletion
2. duplication
3. inversion
4. substitution
5. translocation

deletion - type of chromosomal mutation in which there is an absence of a segment of
DNA (single base or entire gene)

duplication - type of chromosomal mutation in which there is a presence of an extra
segment of DNA (redundant copies)

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