436 - L15 - locus control region Actual Questions And Complete Detailed Answers.
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Module
LCR
Institution
LCR
The locus control region (LCR) - correct answer coordinates expression of individual genes in the cluster (ex. the globin genes or 4 HOX gene clusters)
The individual genes are activated in a temporal sequence (stage specific in development) (not sp...
The locus control region (LCR) - correct answer coordinates expression of
individual genes in the cluster (ex. the globin genes or 4 HOX gene clusters)
The individual genes are activated in a temporal sequence (stage specific in development) (not spatially
as in tissue specific) - correct answer tends to correspond exactly with their
linear order in the chromosome
Globin genes: - correct answer have clear developmental stage specific
expression (diff genes activated at the embryonic, fetal and adult stage to generate diff hemoglobins)
Both the alpha and beta globins are single gene cluster families - correct answer
beta globin: epsilon = embryonic, gamma = fetal, and beta (+delta) switch 2 to adult expression (these
are switched by LCR!)
Alpha is more simple with one switch occurring - correct answer just before
birth, to the alpha form of expression
LCR of globin genes is located upstream of the cluster - correct answer
organizes the genes into active domains, and acts as enhancers for transcription, and opens the
chromatin to make accessible to DNase I
B-globin LCR is upstream at 3 erythroid specific - correct answer DNase
hypersensitive sites, HS2, HS3, HS4, and interact to form a large complex that interacts with the
individual globin gene
a-globin LCR at an erythroid specific HS DNase site - correct answer HS40, 60
kb upstream
These sites contain enhancer sequences of 200-300 bp - correct answer
including multiple sequence elements recognized by specific transcription factors
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