BBH 432 Exam 3- Stress and Aging I, II & III Test Questions and Correct Answers
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Module
BBH 432
Institution
BBH 432
What is the end replication problem? With consecutive rounds of DNA replication, the ends of the DNA, the telomeres will become shorter and shorter
What is the Hayflick Limit? -Telomere provide a means for "counting" cell division -The number of times a normal human cell population will divide unt...
BBH 432 Exam 3- Stress and Aging I, II &
III Test Questions and Correct Answers
What is the end replication problem? ✅With consecutive rounds of DNA replication,
the ends of the DNA, the telomeres will become shorter and shorter
What is the Hayflick Limit? ✅-Telomere provide a means for "counting" cell division
-The number of times a normal human cell population will divide until cell division stops
-Empirical will get slightly shorter with each new cell division until they shorten to a
critical length (this is what the graph shows)
What are the main functions of telomeres and telomerase? ✅-Telomerase: enzyme
with RNA and protein components, adds telomeric repeat directly to the DNA sequence.
Expressed by germ cells, early embryonic cells and stem cells. Not expressed by most
somatic cells (human), expressed by 80-90% of cancer cells
-Telomeres: ends of linear chromosomes
How can telomerase influence telomeres? ✅Longer telomere length is associated with
fewer numbers of cell doublings due to telomerase.
Why are telomeres important in relation to aging? ✅Telomere length is a marker for
biological aging (wear and tear), rather than a clock for chronological aging
-Shorter telomeres = lower survival rate
-Telomere length in early life predicts lifespan
HeLa cells ✅Derived for the use in cancer research
-Proliferate abnormally and rapidly
-Active version of telomerase
-It circumvents the Hayflick Limit
-Used for research into cancer, AIDS, the effects of radiation and toxic substances,
gene mapping, and many other scientific pursuits
-Scientists have grown some 20 tons of it
-More than 60,000 articles have been published
-11,000 patents
What is the effect of stress on our telomeres? ✅-Stress decreases the number of cell
doublings as well as shorter telomere length
Research examples on telomere length across the lifespan ✅Elissa Epel:
1. 58 healthy women who were biological mothers of either a health child (control
mothers) or a chronically ill child (caregiving mothers)
2. Assessed level of perceived stress over the past month in both groups
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