-Syngeneic
-Matched sibling/related
-Mismatch related
-Matched unrelated
-Mismatched unrelated
-Umbilical cord - ✔✔Specific Types of Allogeneic Transplant (6)
-Identical twin
-No need for immunosuppression, disease free source
-No graft vs tumor effect - ✔✔Syngeneic
(source, advantages, disadvantages)
-HLA matching, non self
-Disease free stem cell source, Potential for graft versus tumor effect
-Graft-versus-host-disease (GVHD), Substantial morbidity and mortality, Donor procurement,
Immunosuppressive medication - ✔✔Allogeneic
(source, advantages, disadvantages)
-self
-Easily available source of stem cells, No risk of graft-versus-host-disease (GVHD), Decreased
morbidity and mortality, Less costly, Early engraftment
-Possible contamination of undetectable stem cells, No opportunity for graft vs. tumor effect. -
✔✔Autologous
(source, advantages, disadvantages)
-Occurs after allogeneic HST
-Immune response to recipient tumor cells by immune cells present in stem cell infusion
-May eliminate residual malignant cells prolonging remission - ✔✔Graft vs Tumor Effect
-Typically faster engraftment: Shorter hospitalization stay
-Can be done outpatient
-Collection is well tolerated: No anesthesia is required
-PBSC's are more mature
-Increased immunologic function: Increased immunologic function compared to bone marrow/UCB -
✔✔Peripheral Blood - Advantages
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