-Syngeneic
-Matched sibling/related
-Mismatch related
-Matched unrelated
-Mismatched unrelated
-Umbilical cord - ✔✔Specific Types of Allogeneic Transplant (6)
-Identical twin
-No need for immunosuppression, disease free source
-No graft vs tumor effect - ✔✔Syngeneic
(source, advantages, disadvantages)
-HLA matching, non self
-Disease free stem cell source, Potential for graft versus tumor effect
-Graft-versus-host-disease (GVHD), Substantial morbidity and mortality, Donor procurement,
Immunosuppressive medication - ✔✔Allogeneic
(source, advantages, disadvantages)
-self
-Easily available source of stem cells, No risk of graft-versus-host-disease (GVHD), Decreased
morbidity and mortality, Less costly, Early engraftment
-Possible contamination of undetectable stem cells, No opportunity for graft vs. tumor effect. -
✔✔Autologous
(source, advantages, disadvantages)
-Occurs after allogeneic HST
-Immune response to recipient tumor cells by immune cells present in stem cell infusion
-May eliminate residual malignant cells prolonging remission - ✔✔Graft vs Tumor Effect
-Typically faster engraftment: Shorter hospitalization stay
-Can be done outpatient
-Collection is well tolerated: No anesthesia is required
-PBSC's are more mature
-Increased immunologic function: Increased immunologic function compared to bone marrow/UCB -
✔✔Peripheral Blood - Advantages
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller AnswersCOM. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £9.12. You're not tied to anything after your purchase.
