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Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) - Maryville £8.97   Add to cart
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Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) - Maryville
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Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) Q: Explain first pass metabolism Answer: much of the drug is lost in the absorption process. The liver metabolizes many drugs, thus reduces t...

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  • September 30, 2024
  • 34
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • nur
  • nurs 615nurs615 latestnurs 615nurs
  • exam 1 nurs 615 nurs615 latest updat
  • when 2 drugs are both metabolized by the p450 syst
  • explain first pass metabolism
  • nurs 615nurs615nurs 615 nurs615 final exam

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  • NURS 615/ NURS615
  • NURS 615/ NURS615

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ExamI1:INURSI615/INURS615I(LatestI2024
/I2025IUpdate)IAdvancedI
PharmacotherapeuticsICompleteIGuideI|QsI
&IAs|I100%ICorrect|IGradeIAI(VerifiedI
Answers)
Q:IExplainIfirstIpassImetabolism

Answer:
muchIofItheIdrugIisIlostIinItheIabsorptionIprocess.ITheIliverImetabolizesImanyIdrugs,IthusIred
ucesItheIbio-availabilityIofItheIdrug.




Q:IWhatIisItheIfastedIrouteIofIabsorption:

Answer:
TheIfastestIrouteIofIabsorptionIisIinhalation,IandInotIasImistakenlyIconsideredItheIIVIadminist
ration.




Q:IWhyIdoesItheIGIItractItakeIlongerItoIabsorb?

Answer:
TheIGIItractIisIlinedIwithIepithelialIcells;IdrugsImustIpermeateIthroughItheseIcellsIinIorderItoI
beIabsorbedIintoItheIcirculatoryIsystem.




Q:IWhatIisIOneIparticularIcellularIbarrierIthatImayIpreventIabsorptionIofIaIgivenIdrug?

,Answer:
theIcellImembrane.ICellImembranesIareIessentiallyIlipidIbilayersIwhichIformIaIsemipermeable
Imembrane.IPureIlipidIbilayersIareIgenerallyIpermeableIonlyItoIsmallIandIunchargedIsolutes,Ih
enceIwhetherIorInotIaImoleculeIisIionizedIwillIaffectIitsIabsorption,IsinceIionicImoleculesIareI
charged.




Q:IWhatIisIsolubility?

Answer:
SolubilityIfavorsIchargedIspecies,IpermeabilityIfavorsIneutralIspecies.ISomeImoleculesIhaveIsp
ecialIexchangeIproteinsIandIchannelsItoIfacilitateImovementIfromItheIlumenIintoItheIcirculatio
n.




Q:IWhyIdoesIabsorptionIoccurIatIaIslowerIrateIforIoral,IIM,ISQIroutes?

Answer:
AbsorptionIoccursIatIaIslowerIrateIbecauseItheIcomplexImembraneIsystemsIofIGIImucosalIlay
ers,Imuscle,IandIskinIdelayIdrugIpassage.




Q:ITheIabilityIofIaIdrugItoIcrossIaIcellImembraneIdependsIon:

Answer:
whetherItheIdrugIisIwaterIorIlipidI(fat)Isoluble.ILipid-
solubleIdrugsIeasilyIcrossIthroughIcellImembranes;Iwater-solubleIdrugsIcan't.ILipid-
solubleIdrugsIcanIalsoIcrossItheIblood-brainIbarrierIandIenterItheIbrain.




Q:IAsIaIdrugItravelsIthroughItheIbody,IitIcomesIinIcontactIwith?

Answer:

,proteinsIsuchIasItheIplasmaIproteinIalbumin.ITheIdrugIcanIremainIfreeIorIbindItoItheIprotein.I
TheIportionIofIaIdrugIthat'sIboundItoIaIproteinIisIinactiveIandIcan'tIexertIaItherapeuticIeffect.I
OnlyItheIfree,IorIunbound,IportionIremainsIactive.IAIdrugIisIsaidItoIbeIhighlyIprotein-
boundIifImoreIthanI80%IofItheIdrugIisIboundItoIprotein.




Q:IIdentifyIdrugImetabolismIandItheIroleIofIisoenzymesIinItheIp450Isystem

Answer:
CYPsIareItheIareItheImajorIenzymesIinvolvedIinIdrugImetabolismIaccountingIforIaboutI75%Io
fItheItotalImetabolism.




Q:INaturallyIoccurringIcompoundsImayIinduceIorIinhibitICYPIactivity.

Answer:
ForIexample,IbioactiveIcompoundsIfoundIinIgrapefruitIjuiceIandIsomeIotherIfruitIjuicesIinclud
ingIdihydroxyIforgottenIandIparasitinIAIhaveIbeenIfoundItoIinhibitICYP3a4ImediatedImetabol
ismIofIcertainImedicationsIleadingItoIincreasedIbioavailabilityIandItheIstrongIpossibilityIofIov
erdosing.




Q:IWhatIdoesIgrapefruitIhaveItoIdoIwithICYP?

Answer:
GrapefruitIisIanIinhibitorIandIwillIdecreaseItheImetabolismIofIdrugsIbyItheIcypIenzymes




Q:IWhenI2IdrugsIareIbothImetabolizedIbyItheIp450IsystemItheIdrugIshouldIbe

Answer:

, administeredIatIseparateItimesItoIpreventItheImetabolismIofIoneIdrugIresultingIinItoxicIeffects
IofItheIotherIdrug.I(becauseIitIwouldIhaveIlessIproteinItoIbindItoo,IthusImoreIfreeIfloatingIdru
g)




Q:IWhatIisItheIefficacyIofIaIdrug?

Answer:
EfficacyIisItheImaximumIresponseIachievableIfromIaIdrug.IEffectivenessIrefersItoItheIabilityIo
fItheIdrugItoIproduceIaIbeneficialIeffect.




Q:IOnItheIdrugIconcentrationIcurveIwhatIisItheIfirstIsignIofIaItherapeuticIeffect?

Answer:
TheIonsetIofIaction




Q:IWhatIisItheIpurposeIofIaIpeakIandItroughIlevel?

Answer:
ToIdetermineIifItheIdrugIisIinItherapeuticIrange.




Q:IDescribeItheIpurposeIofIbloodIbrainIbarrier

Answer:
TheIBBBIisIaIhighlyIselectiveIpermeabilityIbarrierIthatIseparatesItheIcirculatingIbloodIfromIth
eIbrainIandIextracellularIfluidIinItheICNS.ITheIBBBIisIformedIbyIbrainIendothelialIcellsIwhic
hIareIconnectedIbyItightIjunctionsIwithIanIextremelyIhighIelectricalIresistivityIofIatIleastI0.1I
micron.ITheIBBBIallowsItheIpassageIofIwater,IsomeIgases,IandIlipidIsolubleImoleculesIbyIpas
siveIdiffusionIasIwellIasItheIselectiveItransportImoleculesIsuchIasIglucoseIandIaminoIacidsItha
tIareIcrucialItoIneuroIfunction.

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