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Questions and answers for HTHSCI 3I03: Activation of Naive T cell and Killer CD8
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Questions and answers for HTHSCI 3I03: Activation of Naive T cell and Killer CD8
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1-44 of 44What signals do naive T cells require to become fully activated?
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1. TCR binding to specific MHC/peptide
2. Co-stimulatory receptor binding of co-stumulatory ligands
, What cell type is required for proper clean apoptosis to occur?
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Macrophages to phagocytose the components of the dissolved cell
In what two ways can a cell die?
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1. Necrosis: messy cell death due to injury or disease (ex: following trauma
or infection)
2. Apoptosis: organized programmed cell death (ex: removal of cells
during development)
What interaction activates the co-stimulatory pathway?
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CD28 with CD80 or CD86
Describe the killing path of CD8 T cells.
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1. Cytotoxic CD8 T cell recognizes virus-infected cell with MHC I and
antigen specific for TCR
2. CD8 T cell programs first target cell to die
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