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UNE Biochemistry Unit 1 Exam Questions and Answers
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UNE Biochemistry Unit 1 Exam Questions and Answers
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UNE Biochemistry Unit 1 ExamQuestions and Answers
What is primary structure of a protein? - Answers -Linear sequence of amino acids in a
polypeptide chain written from the N-terminus to the C-terminus.
What kind of structure contains a-helices and B-pleated sheets? - Answers -Secondary
structure
How are a-helices formed? - Answers -The CARBONYL group of a peptide bond forms
a HYDROGEN bond with the AMIDE nitrogen of another peptide bond FOUR amino
acids down the chain.
Are a-helices weak and loose or compact and rigid? - Answers -Compact and rigid
a-helices comprise what fraction of secondary structures? - Answers -About 1/3
Which amino acid can cause a kink in a-helices and is therefore not typically found in
them? - Answers -Proline
How are B-pleated sheets formed? - Answers -B strands are connected laterally by at
least two or three hydrogen backbone bonds.
B-pleated sheets are formed laterally between which groups on either B strand? -
Answers -C=O groups and NH groups
In which directions do R groups on B pleated sheets always protrude? - Answers -Up or
down.
If the B-pleated sheet has a hydrophobic side, where is it? - Answers -Buried in the
protein and will rarely be exposed to the polar H2O solvent.
If the B-pleated sheet has a hydrophilic side, where is it? - Answers -On the surface of
the protein and exposed to the polar H2O solvent.
What are bends/turns/loops? - Answers -Shorts stretches of the polypeptide chain that
are stabilized by hydrogen bonds and are NOT random
What is tertiary protein structure? - Answers -The total 3D conformation of the
polypeptide chain including interactions between a-helices, B-pleated sheets and any
loops/turns/bends
, The Rossman fold is an example of what type of structure? - Answers -Tertiary
What is a structural domain? - Answers -A section of protein sufficient to perform a
chemical or physical task. They are DEFINED regions with CONSERVED function.
What is a motif? - Answers -Common arrangement of secondary structures to form a
tertiary arrangement
What is quaternary structure? - Answers -A combination of two or more tertiary subunits
that work as one functioning unit.
What are similarities between myoglobin and hemoglobin? - Answers -They are
homologous. They have similar primary sequences. They both bind oxygen.
What is the function of hemoglobin? - Answers -Travels through the blood inside a red
blood cell in order to deliver oxygen form the lungs to the tissues
What is the function of myoglobin? - Answers -Remains in the heart and the skeletal
muscles in order to bind oxygen that is released by hemoglobin.
What is an apoprotein missing? - Answers -Its ligand. An example is hemoglobin if it
were missing heme.
What is a holoprotein? - Answers -A protein that has its ligand so that it is able to
function.
What is the general structure of myoglobin? - Answers -It is a monomer that has 8 a-
helices bound together by alpha turns.
Myoglobin has a ?? pocket that contains ?? and ?? at its center so that oxygen may
bind. - Answers -hydrophobic pocket, contains heme and fe2+
What is the fe2+ in myoglobin always bound to and what is the purpose of this binding?
- Answers -It is always bound to the histidine R group of the a-helix and this helps to
stabilize
What is heme tightly bound to and what is it considered? - Answers -The globin, a
prosthetic group
When represented on a graph, what kind of binding curve does myoglobin have? -
Answers -Hyperbolic
What is the general structure of hemoglobin? - Answers -It is a heterotetramer (four
subunits, one is different from the others). It has 2 a-helix and 2 B-pleated sheet
subunits. Each has its own heme.
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