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[Show more]MOA - Calcium Channel Blockers - Prevent Calcium ion from entering cells - Greatest impact is on heart, arterioles, and arteries 
Therapeutic uses - CCBs Hypertension, angina pectorals, cardiac dysrhythmias 
Explain the physiologic consequences of calcium channel blockers on vascular smooth muscle C...
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Add to cartMOA - Calcium Channel Blockers - Prevent Calcium ion from entering cells - Greatest impact is on heart, arterioles, and arteries 
Therapeutic uses - CCBs Hypertension, angina pectorals, cardiac dysrhythmias 
Explain the physiologic consequences of calcium channel blockers on vascular smooth muscle C...
Calcium channel blockers (CCBs) lower BP by __________ Vasodilation 
CCBs differ from nitrates in that they do not cause vasodilation of ___________ Veins (venous system) 
Dihydropyridine CCBs primarily affect _________ Arterioles 
The three effects of the CCBs verapamil and diltiazem on the heart a...
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Add to cartCalcium channel blockers (CCBs) lower BP by __________ Vasodilation 
CCBs differ from nitrates in that they do not cause vasodilation of ___________ Veins (venous system) 
Dihydropyridine CCBs primarily affect _________ Arterioles 
The three effects of the CCBs verapamil and diltiazem on the heart a...
Calcium Channel Blockers -CCBs are like "valium" for your heart --Valium calms you down. Therefore, CCB relaxes and slows down the heart ---If the heart is tachycardic, tachyarrhythmia, or heart attack → needs to be rested → GIVE CCB ---If you are in shock, or you are in heart block → needs to...
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Add to cartCalcium Channel Blockers -CCBs are like "valium" for your heart --Valium calms you down. Therefore, CCB relaxes and slows down the heart ---If the heart is tachycardic, tachyarrhythmia, or heart attack → needs to be rested → GIVE CCB ---If you are in shock, or you are in heart block → needs to...
Calcium Channel Blockers Hypertension Angina Pectoris Cardiac dysrhythmias 
CCBs that target both vascular smooth muscle and the hearts NONdihyrdopyridines Verapamil Diltiazem 
CCB that targets vascular smooth muscle only DIHYDROPYRIDINES Nifedipine 
Calcium channel open Contractile process 
Calcium...
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Add to cartCalcium Channel Blockers Hypertension Angina Pectoris Cardiac dysrhythmias 
CCBs that target both vascular smooth muscle and the hearts NONdihyrdopyridines Verapamil Diltiazem 
CCB that targets vascular smooth muscle only DIHYDROPYRIDINES Nifedipine 
Calcium channel open Contractile process 
Calcium...
All CCB are racemic mixtures except? Dilt and Nifedipine 
Non-Dihydropyridines Verapamil and diltiazem 
Dihydropyridines Nifedipine, Nicardipine, Nimodipine, Felodipine, Isradipine, Nisoldipine Amlodipine, Clevidipine 
Adverse affects of CCBs are similar except that dihydropyridines never cause what...
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Add to cartAll CCB are racemic mixtures except? Dilt and Nifedipine 
Non-Dihydropyridines Verapamil and diltiazem 
Dihydropyridines Nifedipine, Nicardipine, Nimodipine, Felodipine, Isradipine, Nisoldipine Amlodipine, Clevidipine 
Adverse affects of CCBs are similar except that dihydropyridines never cause what...
nondihydropyridine CCB include verapamil & diltiazem 
Verapamil is a NDH CCB 
Diltiazem is a NDH CCB 
Nondihydropyridine CCBs can be used to treat - HTN - stable angina - arrhythmias - atrial fibrillation 
NDH CCB deacrease HR & slow AV node conduction * may cause bradycardia & AV block * 
Counselin...
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Add to cartnondihydropyridine CCB include verapamil & diltiazem 
Verapamil is a NDH CCB 
Diltiazem is a NDH CCB 
Nondihydropyridine CCBs can be used to treat - HTN - stable angina - arrhythmias - atrial fibrillation 
NDH CCB deacrease HR & slow AV node conduction * may cause bradycardia & AV block * 
Counselin...
A diabetic patient suffers from effort angina, they have tried beta blockers before but are worried about experiencing a hypoglycemic incident while on the beta blocker. What would be the next best drug to treat this patient's angina? a. Verapamil b. Nifedipine c. Metoprolol d. Bumetanide ANS: A - v...
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Add to cartA diabetic patient suffers from effort angina, they have tried beta blockers before but are worried about experiencing a hypoglycemic incident while on the beta blocker. What would be the next best drug to treat this patient's angina? a. Verapamil b. Nifedipine c. Metoprolol d. Bumetanide ANS: A - v...
Ca2+ Channel Blockers (CCBs) groups Dihydropyridine (DHP) groups 
NonDihydropyridine groups 
Dihydropyridine (DHP) groups *Amlodipine (Norvasc®) Felodipine Isradipine Nicardipine Nifedipine (Procardia®) Nimodipine Nisoldipine 
NonDihydropyridine groups *Verapamil (Calan®) Diltiazem (Cardizem®) 
...
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Add to cartCa2+ Channel Blockers (CCBs) groups Dihydropyridine (DHP) groups 
NonDihydropyridine groups 
Dihydropyridine (DHP) groups *Amlodipine (Norvasc®) Felodipine Isradipine Nicardipine Nifedipine (Procardia®) Nimodipine Nisoldipine 
NonDihydropyridine groups *Verapamil (Calan®) Diltiazem (Cardizem®) 
...
What are the three main classes of calcium channel blocking drugs? 1. Dihydropyridine 2. Benzothiazepines 3. Phenylalkylamines 
What drug is the benzothiazepine prototype? Diltiazem 
What drug is the phenylakylamine prototype? Verapamil 
What is the common suffix used by the dihydropyridine class? -...
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Add to cartWhat are the three main classes of calcium channel blocking drugs? 1. Dihydropyridine 2. Benzothiazepines 3. Phenylalkylamines 
What drug is the benzothiazepine prototype? Diltiazem 
What drug is the phenylakylamine prototype? Verapamil 
What is the common suffix used by the dihydropyridine class? -...
What is the ion that is important for the depolarization of the nodal cell? Ca++ 
What are the potential effects of CCBs? 1) Reduce cardiac Automaticity 2) Reduce AV nodal conduction 3) Cause vasodilation 
What are the three main chemical classes of CCBs? 1) Phenylalkylamines 2) Benzothiazepines 3) ...
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Add to cartWhat is the ion that is important for the depolarization of the nodal cell? Ca++ 
What are the potential effects of CCBs? 1) Reduce cardiac Automaticity 2) Reduce AV nodal conduction 3) Cause vasodilation 
What are the three main chemical classes of CCBs? 1) Phenylalkylamines 2) Benzothiazepines 3) ...
Currently, all CCBs on the market target the __-type voltage activated calcium channel. 
 
A) T 
B) N 
C) R 
D) L 
E) P/QD) L 
 
*Currently, all CCBs on the market traget the L-type channel.* 
 
CCBs have greater effect on *arterial* or *venous smooth muscle.*CCBs have greater effect on *arterial sm...
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Add to cartCurrently, all CCBs on the market target the __-type voltage activated calcium channel. 
 
A) T 
B) N 
C) R 
D) L 
E) P/QD) L 
 
*Currently, all CCBs on the market traget the L-type channel.* 
 
CCBs have greater effect on *arterial* or *venous smooth muscle.*CCBs have greater effect on *arterial sm...
calcium channel blockers Effect the heart, and blood vessels. CCBs are widely used to treat hypertension, angina pectoris and cardias dysrhythmias. 
 
calcium and the heart Calcium regulates contraction in vascular smooth muscle and cardiac muscle. In cardiac/vascular smooth muscle (VSM), the influx...
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Add to cartcalcium channel blockers Effect the heart, and blood vessels. CCBs are widely used to treat hypertension, angina pectoris and cardias dysrhythmias. 
 
calcium and the heart Calcium regulates contraction in vascular smooth muscle and cardiac muscle. In cardiac/vascular smooth muscle (VSM), the influx...
Calcium Channel Blockers (CCBs) CCBs work by decreasing calcium entry through calcium channels. By regulating the movement of calcium, contraction of vascular smooth muscle is controlled, which causes blood vessels to dilate. This reduces blood pressure and workload on the heart, so this type of med...
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Add to cartCalcium Channel Blockers (CCBs) CCBs work by decreasing calcium entry through calcium channels. By regulating the movement of calcium, contraction of vascular smooth muscle is controlled, which causes blood vessels to dilate. This reduces blood pressure and workload on the heart, so this type of med...
The primary cause of angina pectoris is an imbalance between --- --- of the heart and --- --- to the heartoxygen requirement; oxygen supply 
episodes of angina in unstable angina occur at --rest 
unstable angina is typically caused by -- -- around an atherosclerotic plaque causing a reduction in blo...
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Add to cartThe primary cause of angina pectoris is an imbalance between --- --- of the heart and --- --- to the heartoxygen requirement; oxygen supply 
episodes of angina in unstable angina occur at --rest 
unstable angina is typically caused by -- -- around an atherosclerotic plaque causing a reduction in blo...
Main effects of CCBs (3) Slow HR 
Decrease BP 
SM relaxation 
3 classes of dihydropyridines CCBs End in -Dipine 
1st gen (NNN) 
2nd gen (FINc) 
3rd gen (amlodipine) 
3 classes of non-selective CCBs (Non-dihydropyridines) Phenylalkylamines 
Benzothiazepines 
Phenylbenzylamine 
Indications of CCBs (4)...
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Add to cartMain effects of CCBs (3) Slow HR 
Decrease BP 
SM relaxation 
3 classes of dihydropyridines CCBs End in -Dipine 
1st gen (NNN) 
2nd gen (FINc) 
3rd gen (amlodipine) 
3 classes of non-selective CCBs (Non-dihydropyridines) Phenylalkylamines 
Benzothiazepines 
Phenylbenzylamine 
Indications of CCBs (4)...
Why is cyclin D frequently amplified or over-expressed in human cancers? know that cyclin D is the initiator of the G1 phase of cell cycle and works as the other kinase complexes fluctuates. over expression of cyclin D in turn leads to increased cell division and growth 
Which part of the cell cycle...
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Add to cartWhy is cyclin D frequently amplified or over-expressed in human cancers? know that cyclin D is the initiator of the G1 phase of cell cycle and works as the other kinase complexes fluctuates. over expression of cyclin D in turn leads to increased cell division and growth 
Which part of the cell cycle...
CCBs mechanism inhibit Ca2+ influx through L-type (voltage gated) calcium channels (LTCC) 
CCBs actions act on Ca2+ entry into vascular smooth muscle (vasodilate), cardiac muscle (decrease force of contraction), SA nodal tissues (reduce contraction rate), AV node (decrease conduction velocity) 
Ther...
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Add to cartCCBs mechanism inhibit Ca2+ influx through L-type (voltage gated) calcium channels (LTCC) 
CCBs actions act on Ca2+ entry into vascular smooth muscle (vasodilate), cardiac muscle (decrease force of contraction), SA nodal tissues (reduce contraction rate), AV node (decrease conduction velocity) 
Ther...
A 57-year-old woman comes to the physician because of a 2-week history of swelling of both her feet. It improves a little bit with elevation but still is bothersome to her because her shoes no longer fit. She has type 2 diabetes mellitus treated with metformin and linagliptin. She was diagnosed with...
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Add to cartA 57-year-old woman comes to the physician because of a 2-week history of swelling of both her feet. It improves a little bit with elevation but still is bothersome to her because her shoes no longer fit. She has type 2 diabetes mellitus treated with metformin and linagliptin. She was diagnosed with...
CCB absorption nearly complete (low secretion), but most have significant first past effect 
CCB distribution high protein binding (ex. albumin, glycoproteins); low distribution and high restriction to vascular compartments 
CCB metabolism CYP3A4 (first pass effect and drug interactions) 
CCB elimin...
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Add to cartCCB absorption nearly complete (low secretion), but most have significant first past effect 
CCB distribution high protein binding (ex. albumin, glycoproteins); low distribution and high restriction to vascular compartments 
CCB metabolism CYP3A4 (first pass effect and drug interactions) 
CCB elimin...
True or False; All Calcium Channel Blockers are racemic mixtures? False diltiazem & nifedipine are not 
ALL the other currently available CCB's are administered as racemic mixtures 
What are the three chemical structure classification? Phenylalkylamines, Benzothiazepines, 1,4-Dihydropyridines 
What...
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Add to cartTrue or False; All Calcium Channel Blockers are racemic mixtures? False diltiazem & nifedipine are not 
ALL the other currently available CCB's are administered as racemic mixtures 
What are the three chemical structure classification? Phenylalkylamines, Benzothiazepines, 1,4-Dihydropyridines 
What...
What are the L-type Calcium Channel Blockers (CCB)? Non-DHP, oral DHP, IV DHP. Non-DHP: - Verapamil - Diltiazem 
oral DHP: - Nifedipine - Amlodipine 
IV DHP: - Nicardipine - CLevidipine 
CCB Pharmacokinetics (bioavailability, metabolism, half life) Bioavailability: - good oral absorption but reduced...
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Add to cartWhat are the L-type Calcium Channel Blockers (CCB)? Non-DHP, oral DHP, IV DHP. Non-DHP: - Verapamil - Diltiazem 
oral DHP: - Nifedipine - Amlodipine 
IV DHP: - Nicardipine - CLevidipine 
CCB Pharmacokinetics (bioavailability, metabolism, half life) Bioavailability: - good oral absorption but reduced...
Prototype for calcium channel blocker that affect the heart and blood vessels Verapamil 
Prototype for calcium channel blocker that is a dihydropyridines: Agents that act mainly on blood vessels Nifedipine 
Safety Alert: Immediate-release nifedipine has been associated with increased mortality in pa...
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Add to cartPrototype for calcium channel blocker that affect the heart and blood vessels Verapamil 
Prototype for calcium channel blocker that is a dihydropyridines: Agents that act mainly on blood vessels Nifedipine 
Safety Alert: Immediate-release nifedipine has been associated with increased mortality in pa...
Complete the phrase: Calcium channel blockers (CCBs) lower blood pressure by ________________: vasodilation 
Complete the phrase: CCBs differ from nitrates in that they do not cause vasodilation of _______________: veins (venous system) 
Complete the phrase: Dihydropyridine CCBs primarily affect ___...
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Add to cartComplete the phrase: Calcium channel blockers (CCBs) lower blood pressure by ________________: vasodilation 
Complete the phrase: CCBs differ from nitrates in that they do not cause vasodilation of _______________: veins (venous system) 
Complete the phrase: Dihydropyridine CCBs primarily affect ___...
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