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Summary AANP/ANCC Antibiotic Review

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  • Course
  • Family nurse practitioner
  • Institution
  • Family Nurse Practitioner

This document is an excellent review of antibiotics for the AANP/ANCC Family Nurse Practitioner Exam.

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  • Antibiotics
  • February 25, 2021
  • 3
  • 2020/2021
  • Summary
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  • Family nurse practitioner
  • Family nurse practitioner

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By: kristen_rothe • 1 year ago

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Antibiotics
Bactericidal: kill bacteria Bacteriostatic: limit bacterial growth and replication Tetracyclines : Cat D: doxycycline, minocycline, tetracycline Bacteriostatic
Cause permanent discoloration of teeth and skeletal defects if taken in last ½ of pregnancy, in infancy, or by kids younger than 9
Can treat acne starting at age 13-14 because all permanent teeth have erupted Photosensitivity (wear sunblock), esophageal ulceration (swallow w/ full glass of water), vertigo (minocycline- goes away after 1-2 after d/c) Give tetracycline for moderate inflammatory acne that doesn’t respond to prescription topicals after 2-3 months Take on empty stomach- 1 hr before or 2 hrs after a meal. Antacids and bile sequestrants and sucralfate can decrease absorption Can decrease effectiveness of birth control! Throw away expired meds- it degenerates For mild acne: start with OTC topicals (salicylic acid) and benzoyl peroxide If it doesn’t respond: prescription topicals (benzoyl peroxide, erythromycin/benzamycin), tretinoin (Retin-A), azelaic acid cream Macrolides : Cat B: erythromycin, azithromycin, clarithromycin (Cat C) Bacteriostatic
Gram + cocci- Staph aureus, Strep pyogenes, and atypical bacteria Erythromycin & clarithromycin= CYP34A inhibitors- potent
Azithromycin- fewer drug interactions Adverse effects: GI distress (nausea, vomiting, diarrhea), ototoxicity, cholestatic jaundice, QT prolongation Contraindication: Myasthenia gravis (respiratory failure)
Interactions: anticoagulants (can prolong INR), antacids (decrease effectiveness), calcium channel blockers, benzos, asthma meds (Salmeterol, Theophylline), Tegretol, phenytoin, ergotamine, statins, Digoxin Consider macrolide resistant S. pneumoniae if pt was on macrolide in the previous 3 months Cephalosporins : Cat B (beta-lactam family)
Bactericidal 1st generation: gram + cocci (group A step, Staph aureus): Keflex
NOT EFFECTIVE against MRSA Increased risk of cross sensitivity if allergy to PCN- especially if they have a true allergy (anaphylaxis, angioedema= IgE mediated reactions)
Indications: Pregnancy UTI, skin- cellulitis not caused by MRSA, impetigo Would give this for pregnant woman with UTI in her 3rd trimester- remember this because in the third trimester you Kick the baby out 2nd generation: “broad spectrum”: Cefuroxime, Cefprozil, Cefaclor (avoid- doesn’t cover common pathogens)
Gram + cocci (strep pneumoniae) and gram – (Haem. Influenzae, moraxella catarrhalis) ex. Rhinosinusitis or AOM Indications: rhinosinusitis, ARM, CAP, exacerbation of chronic bronchitis
3rd generation: less effective against gram + compared to 1 st generation: Ceftriaxone, Cefixime, Cefdinir Better protection against enterobacteria and gram – bacteria Rocephin: 1st line for gonorrhea Indications: PID, pyelonephritis, AOM in kids, rhinosinusitis, AOM, CAP MRSA skin infections (boils, abscesses): 1 st line= Bactrim DS, doxy, or minocycline and clindamycin. Treat for at least 5-10 days

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