These summaries (in English and provided with many supporting figures from the book) will help you to obtain a great grade for the course 'Genetics' in the first year of Biomedical Sciences at the VU. With learning al my summaries and lecture notes (see my other documents), I finished this course w...
Summary ISE Genetics Analysis and Principles - Genetics Part 2!!
Chapter 1, overview of genetics
Complete Test Bank Genetics Analysis and Principles 7th Edition Brooker Questions & Answers with rationales (Chapter 1-29)
All for this textbook (60)
Written for
Vrije Universiteit Amsterdam (VU)
Bachelor Biomedical Sciences
Genetics
All documents for this subject (37)
1
review
By: saroongao • 10 months ago
Seller
Follow
simonezweers19
Reviews received
Content preview
Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
Chapter 16: Gene regulation in eukaryotes II: epigenetics
1
, Genetics summary – VU BMS 2020/2021
Simone Zweers
Reference: Brooker, Genetics: Analysis and prinicples, 7th edition
- Epigenetics is a field of genetics that explores changes in gene expression that may be
permanent over the course of an individual’s life but are not permanent over the course
of multiple generations
- Epigenetic changes responsible for the establishment and maintenance of gene
activation/repression enable cells to remember past events
16.1: Overview of epigenetics
- Epigenetic effect begins with an initial event that causes a change in gene expression
change must be passed from cell to cell and must not involve a change in the DNA
sequence
- Embryonic development genes that will become muscle cells are inhibited by
epigenetic changes like DNA methylation adult muscle cell will not express the
inhibited genes
- Other epigenetic changes may be reversible during the life
- Epigenetics is the study of mechanisms that leas to changes in gene expression that
can be passed from cell to cell and are reversible, but do not involve a change in the
sequence of DNA. This type of change may also be called an epimutation – a heritable
change in gene expression that does not alter the DNA sequence
- (Transgenerational) epigenetic inheritance when the change is passed from parent to
offspring via gametes
Different types of molecular changes underlie epigenetic gene regulation
- Most common are DNA methylation, chromatin remodeling, covalent histone
modification, histone variants, feedback loops
- They can also be involved in non-epigenetic changes (transient)
Epigenetic changes
may be targeted to specific genes by transcription factors or non-coding RNAs
- Transcription factors may bind to a specific gene and initiate a series of events that lead
to an epigenetic modification
- They recognize specific sites in the genome
and recruit proteins, like histone-modifying
enzymes and DNA methyltransferase to
those sites (a)
- Or ncRNAs are involved in establishing an
epigenetic modification can act as
bridges between specific sites in the DNA
and proteins that alter chromatin or DNA
structure (b)
2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller simonezweers19. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.88. You're not tied to anything after your purchase.
