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Samenvatting Klinische biologie hoofdstuk 2 deel 1
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deel 1 van H2, alles is er in vermeld
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H2: Mitochondriale koolstofverbrandingBestaat uit 2 stappen die op elkaar aansluiten:
1. Oxidatieve decarboxylering: pyruvaat → acetyl-CoA dmv een PDH-complex.
-Irreversibel
-sterk gereguleerd
2. Krebscyclus of citroenzuurcyclus: metabole cirkel waarin acetyl-CoA van vorige
stap binnentreedt en in 9 stappen w geoxideerd tot 2CO2.
-1 GTP of ATP
-3 NADH
-1 FADH2
Mitochondriën
=celorganellen gespecialiseerd in: (2 processen)
1) Oxidatie van koolstof van pyruvaat, VZ en AZ
2) Omzetting van verbrandingsenergie in ATP
Oxidatieve decarboxylering - algemeen
2 stappen die op elkaar aansluiten:
Oxidatieve carboxylering = connectie tussen glycolyse en krebscyclus.
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