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Pregnancy in Rh- negative Women

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  • June 29, 2021
  • 49
  • 2020/2021
  • Class notes
  • Dr. kinyua
  • Pregnancy in rh-negative women
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KENNEDY K.

PREGNANCY IN A RH-NEGATIVE
WOMAN

,OBJECTIVES

▪ By the end of this lesson we should be able
to:
 Define rhesus and ABO incompatibility
 Outline the pathophysiology of Rhesus
isoimmunization
 Discuss the antenatal and postnatal management
of rhesus incompatibility in pregnancy
 Outline the prevention of rhesus isoimmunization
 State when the anti-D is given

,Introduction

▪ Landsteiner and Weiner in the year 1940,
discovered specific unknown antigen in the
human red cells.
▪ As it was also present in the Rhesus monkeys,
the antigen was named Rh.
▪ The individual having the antigen is called
Rh-positive and in whom it is not present, is
called Rh-negative.

, Incidence
▪ The incidence of Rh-negative is about 15–17%
▪ About 60% of Rh-positive men are heterozygous
and 40% are homozygous at the D locus.
▪ Overall a Rh-negative woman having the chance
of Rh-positive fetus is 60%, irrespective of the
father’s genotype

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