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Summary PHY1601 metabolic system mindmap
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Mindmap of metabolic system
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*CytosolGLYCOLYSIS ppp CHOLESTEROL
PENTOSE PHOSPHATE SYNTHESIS
Glucose
PATHWAY Cholesterol esters
GLYCOGENESIS
PURINE Cell membranes
G-1-P G-6-P Ribulase-6-phosphate Ribose-5-phosphate Steroids
(Irreversible redox stage) SYNTHESIS Cholesterol VIT D
Bile salts
F-6-P
(Reversible interconversion stage)
*Li
SYNTHESIS
Glycogen *RBC & nondividing cells Hypoxanthine ver
*Stored in liver
Lansterol 7-dehydrocholesterol
PURINE (pro-Vitamin D)
and muscle F-1,6-BP
Xanthine METABOLISM *Skin(UV)
Xanthine
LEUBERING-RAPPOPORT oxidase KETOGENESIS Cholecalciferol
Adipose tissue DHAP GA3P HMG-CoA
SHUNT Uric acid *Mitochondrial
(D3)
matrix
Glycerol-3-P 1,3-BP-Glycerate *Liver
2,3-Diphosphoglycerate Calcidiol
Glycerol-1-P 3-Phosphoglycerate ALCOHOL Acetoacetyl CoA
Acetoacetic acid (25-hydroxy VitD)
BREAKDOWN
*Kidney
Glycerol Phosphoenolpyruvate Ethanol
Calcitriol
2 x Acetyl CoA (1,25-dihydroxy Vit D)
GLUCONEOGENESIS Acetaldehyde
Acetone β-hydroxybutarate
*Liver
Body
Acetate
proteins
Pyruvate dehydrogenase (Irreversible)
Alanine Pyruvate Acetyl-CoA
*From muscle *Mitochondria TRANSAMINATION REACTION
tyl-
*Muscle Cori cycle Ace
LIPOLYSIS
N aining ain Aspartate
I O
Lipase
*Liver T em ch
Lactate
X IDA R CoA
β-O
Glutamine Glutamate Alanine GLUCONEOGENESIS
GLUCONEOGENESIS *Excreted by
*Liver *Liver
kidneys
LIPOGENESIS
HAEM BREAKDOWN
TAG Fatty acid Malonyl-CoA
Lipase
*Spleen *Kidney Urine
FATTY ACID SYNTHESIS Biliverdin Bilirubin
*Cytosol *Liver Bile Faeses
*Intestine
Citrate *MM *Cytosol
Aspartate Oxaloacetate Haem Protoporphyrin Protoporphyrinogen Coproporphyrinogen
IX IX III
Isocitrate
Malate TCA CYCLE
UREA *Mitochondrial α-ketoglutarate *Cytosol Uroporphyrinogen III
5-Aminolinoleic Porphobilinogen
CYCLE Fumarate matrix(MM)
acid Uroporphyrinogen I
*MM
*Cytosol & MM of Succinyl-CoA
hepatocytes Succinate HEAM SYNTHESIS
Urea
, HOMEOSTASIS INTERMEDIARY METABOLISM
basiclivingunit
cells aggregates of differentcells held together by intracellular supporting structures organ
fluidcompartments 60 body fluid Icf 40 l of bodyweight
CCF 20 l of body weight Blood plasma interstitial fluid
CCfi largeamounts of Nat ch g Hoos ions ICF i large amounts of Kt Mg P ions
nutrients
Oz glucose fd aa
CO2 4 other waste transported to
lungs kidneys for excretion
internal environment
t
in constant motion transported in circulating blood mixed between blood
tissue fluids by diffusion through capillary walls
ions nutrients surrounds all cells
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