Haematopoiesis
- Blood formation
- Starts during embryonic development throughout childhood / adulthood
- Embryo
○ Mesenchymal cells in yolk sac form blood island
○ Migrate to liver / spleen in between 6 weeks - 7 months
§ Serve as primary site for Haematopoiesis
- 3 months before birth
○ Red Bone marrow becomes major location for Haematopoiesis
○ Mostly the only site for Haematopoiesis
○ Every single bone filled with red bone marrow as they have the
ability to form blood cells
○ After red bone marrow replaced so less ability to form blood cells
- Adult
○ Red bone marrow found in axial skeleton and proximal ends of long
bones
- Originate from pluripotent stem cell in red bone marrow
○ Differentiate into
§ Myeloid stem cell
□ Further differentiate into stem cells
§ Lymphoid stem cells
§ Both lineages experience numerous differentiate to reach
final cells
Erythrocytes
- Histological ruler
○ Use to identify size of surrounding tissues
- Most abundant formed element of blood
- Biconcaved shaped
- Non-nucleated / devoid of other organelles
- Transports O2 and CO2
- Cytoplasm contains haemoglobin
○ Makes blood red
○ O2 binds to haeme group
○ More haemoglobin in peripheral
§ More red stain in red blood cells on peripheral
- Regulation
○ Short life cycle
§ 120 days
§ Bone marrow keeps producing new erythrocytes
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