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Samenvatting Geneesmiddelenlijst Farmacologie en Farmacokinetiek
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GENEESMIDDELENLIJST FARMACOPrototype in vet
Medicijn Werking Receptor Indicatie
BOEK 2
Cholinerge
transmissie
Acetylcholine Agonist Muscarine-R
(mAChR)
Pilocarpine Agonist Muscarine-R Gesloten hoek
(mAChR) glaucoom
Nicotine Agonist Nicotine-R (nAChR)
Varenicline Partiële agonist Nicotine-R (nAChR)
(2*alpha4 en
3*beta2)
Edrofonium Competitieve antagonist AchE
Fysostigmine Reversibele remmer via AchE Open hoek
carbamyleren actieve site glaucoom
Neostigmine Reversibele remmer via AchE Open hoek
carbamyleren actieve site glaucoom
Parathion Irreversibele remmer via AchE
fosforyleren actieve site
Sarin Irreversibele remmer via AchE
fosforyleren actieve site
Pralidoxime AChE-reactivator in geval van AchE
fosforylatie actieve site
Atropine Antagonist Muscarine-R Anesthesie
(mAChR) oa.
Pachycurares Competitieve antagonist Nicotine-R (nAChR)
Leptocurares Depolariserende blokkers Nicotine-R (nAChR)
(continue depolarisatie →
paralyse)
Adrenerge
transmissie
Clonidine Adrenerge agonist: direct- Alfa2-receptor Hoge
werkende sympathomimetica bloeddruk
Dobutamine Adrenerge agonist: direct- Beta1-R Hart-
werkende sympathomimetica aandoeningen
Salbutamol Adrenerge agonist: direct- Beta2-R Astma
werkende sympathomimetica
Fenoxybenzamine Irreversibele adrenerge Alfa1- en alfa2-R Hypertensieve
antagonist: alpha-blokker crisis
Propanolol Adrenerge antagonist: niet- Beta1- en beta2-R Hoge
selectieve beta-blokker bloeddruk
Atenolol Adrenerge antagonist: Beta1-R Hoge
selectieve beta-blokker bloeddruk
1
, DA, 5-HT en
purinerge
transmissie
Dopamine Dopaminerge agonist Dopamine-R
Domperidone Dopaminerge antagonist D2-R in chemo- Braken,
(Motilium) receptor trigger nausea
zone
Buspirone Serotonerge agonist 5-HT1A Anxiolyticum
Sumatriptan Serotonerge agonist 5-HT1B/D Migraine
Cisapride Serotonerge agonist 5-HT4 Refluxziekte
Granisetron Serotonerge antagonist 5-HT3 Braken,
nausea
Caffeïne Purinerge antagonist → P1-R → adenosine Slaap
inhibitie fosfodiësterase receptor subtype
A1
Theofylline Purinerge antagonist → P1-R → adenosine Astma
inhibitie fosfodiësterase receptor subtype
A1
BOEK 3
Depressie
Fluoxetine Anti-depressivum, SSRI: houdt Uptake 1 Depressie
de transporter (uptake 1 mech) transportew = SERT
voor het recycleren van
serotonine in een
geoccludeerde toestand zodat
NT niet gerecycleerd kan w
(werkt selectief)
Reboxetine Anti-depressivum: NA reuptake NET Depressie
inhiberen (werkt selectief)
Clomipramine TCA’s: reuptake mechanismen SERT en NET (met Depressie
van serotonine en NA neveneff)
inhiberen
Venlafaxine SNRI: reuptake mechanismen SERT en NET Depressie
van serotonine en NA (minder neveneff)
inhiberen
Bupropion NA reuptake en dopamine NET en dopamine Depressie
reuptake inhiberen re-uptake
transporter
Phenelzine MAO inhibitor: metabolisatie MAO-A en B, Depressie
van NA, serotonine en irreversibel
dopamine inhiberen
Moclobemide MAO inhibitor Enkel A en Depressie
reversibel
Senegiline MAO inhibitor Enkel B en Parkinson
irreversibel
2
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