Class notes
Agonist and antagonists
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Lecture notes of 11 pages for the course Medicine at QUB (Pharmacology)
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AGONISTIANTAGONISTMolecular targets include
PROTEINS Ion channels membrane
transporters
enzymes extracellular proteins receptors
NUCLEIC ACIDS
MISCELLANEOUS Metal ions gastrointestinal contents
RECEPTORS proteintarget which insidearon
maybe
cell surface with which
anaturallyoccurringchemical
mediator hormone neurotransmitter binds specifically
to initiate a cellular response
Molecules that are no lecutestoo
g
small
large orhydrophilic
enough and
f tooresothecou
I
hydrophicpaso membrane on
rely
through the CHEMICAL car surface receptors
membrane MEDIATORS
passthrough the
membrane and
directly
activate intra
oeuular
Receptor
proteins
, Receptors undergo subtle changes in shape Chemical
mediator on binding courses a onrape
change which stabalises active
form of receptor enhances
interaction with
signal transduction
mechanism
Occupation of a receptor by a drug
doesn't necessarily result in receptor
activation
stages of interaction Binding t
2
activation
I
t Unable to initiate
Binds t activates shapechange
Factors that affect size of responseto a receptoragonist
1 Concentration of
drug in vicinity of receptor at a
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