Class notes
Drug handling part 1
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Lecture notes of 9 pages for the course Medicine at QUB (Pharmacology)
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General scheme of action ofdrug
Drugresponse in determined its concentration
by
at its site of action which is in equilibrium.to the
concentration obtained in blood that is achieved
with the dose given
Pharmaco dynamics The ur apoetic response
levels of response depends on interaction with car
components such as receptors and Cal signalling
processes
Relates the conc in tissues to its therapeutic
drug
affect
Pharmacokinetics What the does to the
body
drug
Relates the dosage to the con C of
drug in plasma
FATE OF DR U G I N THE BODY OR A L CAD M E
Drug Absorption movement of
drug from sitet
of administration in the body 10 site of Meas women
, Drug distribution Reversable transfer of
absorbed into and out of various tissues
drug
in the from the blood stream
body
Drug metabolism Conversion of drug to usually
a move water soluble component
Drug excretion Loso of unchanged
drug from
the in the urine or faeces Cindeudes
body biliary
excretion
Elimination Metabolism Excretion I E
the eventual loss of the from the
drug body
both these
through processes
Disposition Distribution t Elimination I E
refers to all processes that occur after the
drug
has been absorbed I firstpass effect
T bioavailability
FIRST PASS EFFECT
9
Dose that
makes into
Where the concentration thesystemic
system
of a in q
drug greatly
reduced before it reaches
the systemic circulation
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