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Renin system
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Lecture notes of 5 pages for the course Medicine at QUB (Physiology)
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Renin angiotensinaldosterone system
A critical
regulator of blood volume t
systemic vascular
resistance
Important in longtermregulation of B P
Composed of 3 major compounds
Renin Juxtaglomelular cells in kidneys
Aldosterone adrenal cortex T Natl H2O reabsorption
Angiotensin 11 vasoconstriction
d Nat haemorrhage blood volume
Dehydration
dB P Juxta glomerular cells in
kidneys secrete renint
Liver secretes angiotensinogen Angiotensin 9 Angio 1
travels to liver 1 angiotensin convertingenzyme Ace
Vasoconstriction of arterioles t TB F
Angiotensin 2
Adrenal cortex releases aldosterone T Nat and H2O
reabsorption t T k t and Ht excretion in kidneys ALL
T blood volume
A Stimulus d perfusion pressure of detected by
kidney
baro receptors
Cause Severe dehydration
Hypovalaemia
Haemorrhage
, B Stimulus to Nat in DC 1 detected in macula densa cells
Cause i electrolytes
in glomelular filtrate
c Stimulus Sympathetic stimulation of J G A
cause Stress trauma via Bi adrenergic receptor
activation
A B
c
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