Class notes
TUMORS OF STOMACH
- Course
- Institution
- Book
High yield notes of stomach cancers with all important concepts. Quick review.
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
More summaries for
-
Robbins adn cortan pathology, Neoplasia chapter 7 summery
-
ROBBINS AND COTRAN PATHOLOGIC BASIS OF DISEASE, Ninth Edition Anki flashcard
-
Necrosis
Seller
Follow
Hussain998
Content preview
TUMORS OF STOMACHBENIGN TUMORS
Polyps are the most common benign tumors of stomach. Polyps may develop as a result of
epithelial or stromal cell hyperplasia, inflammation, ectopia, or neoplasia.
1. Inflammatory and Hyperplastic polyps
Approximately 75% of all gastric polyps are inflammatory or hyperplastic polyps
Chronic gastritis that initiates the injury and reactive hyperplasia that cause polyp growth
If associated with H. pylori gastritis, polyps may regress after bacterial eradication.
Risk of dysplasia is increased in polyps larger than 1.5 cm.
2. Fundic Gland Polyps
Occur sporadically and in individuals with familial adenomatous polyposis (FAP).
Prevalence increased recently because of increasing use of PPIs which inhibit acid
secretion → increased gastrin secretion → increased oxyntic cell growth.
Fundic gland polyps occur in the gastric body and fundus
Composed of cystically dilated glands lined by Parietal and Chief cells.
, MALIGNANT TUMORS
1. Gastric Adenoma
Represent up to 10% of all gastric polyps.
Usually between 50 and 60 years of age, and males are affected three times more often than
females. Incidence of adenomas is increased in individuals with FAP.
Almost always associated with chronic gastritis with atrophy and intestinal metaplasia.
Risk of adenocarcinoma increased in lesions > 2cm in diameter.
Usually solitary lesions in antrum.
By definition, all gastrointestinal adenomas exhibit epithelial dysplasia, which can be classified
as low or high grade.
Gastric adenomas are premalignant neoplastic lesions with high risk of malignant
transformation.
2. Gastric Adenocarcinoma
Adenocarcinoma is the most common malignancy of the stomach, comprising more than 90% of
all gastric cancers.
Epidemiology
In Japan, Chile, Costa Rica, and Eastern Europe, the incidence is up to 20-fold higher than in
North America, northern Europe, Africa, and Southeast Asia.
Gastric cancer is more common in lower socioeconomic groups and in individuals with
multifocal mucosal atrophy and intestinal metaplasia.
Pathogenesis
H. pylori: Chronic gastritis, most commonly due to H. pylori infection, promotes the development and
progression of cancers ( Intestinal type ).
EBV: While H. pylori is most commonly associated with gastric cancer, approximately 10% of gastric
adenocarcinomas are associated with Epstein-Barr virus (EBV) infection.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Hussain998. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $2.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
64438 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now