LUPUS ERYTHEMATOSUS (DLE/SLE)
>>> PATHO
• Lupus is probably caused by a complex combo of genetic and environmental factors
• 2 main classifications:
o Discoid lupus erythematosus (DLE) – effects only the skin
o Systemic lupus erythematosus (SLE) – more common
• Systemic l...
>>> PATHO
• Lupus is probably caused by a complex combo of genetic and environmental factors
• 2 main classifications:
o Discoid lupus erythematosus (DLE) – effects only the skin
o Systemic lupus erythematosus (SLE) – more common
• Systemic lupus erythematosus (SLE):
o Chronic, progressive, inflammatory connective tissue disorder that can cause
major body organs/systems to fail
o Spontaneous remissions and exacerbations
o Onset may be acute or insidious (slow)
o Potentially fatal, but most live many years
o Autoimmune process – invades organs or deprives them of blood and oxygen
o Immune complexes invade organs directly or cause vasculitis (vessel
inflammation), which deprives the organs of arterial blood and oxygen.
o Autoimmune complexes tend to be attracted to glomeruli of the kidneys
o Often some degree of kidney involvement (lupus nephritis) – this is the leading
cause of death from this disease
o Onset at 20-40 years old
>>> ASSESSMENT
>> PHYSICAL ASSESSMENT
• When in remission pt. may appear
fully healthy
• When disease flares up, pt. may
need to be admitted to the hospital
• MT skin condition daily and at every
home visit
3
, 265 EXAM 4
CHART 18-11 KEY FEATURES – SLE AND SSc
SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) SYSTEMIC SCLEROSIS (SSc)
SKIN Inflamed, red rash on face (“butterfly Inflamed
rash”) Fibrotic
- can appear on other sun-exposed Sclerotic
areas Edematous
- disappears when in remission
Discoid lesions
- worsen when exposed to sunlight or
UV light
- do not disappear, but fade in
remission
RENAL Nephritis Kidney failure
CARIAC Pericarditis (chest pain, SOB, fever) Myocardial fibrosis
Raynaud’s phenomenon (decreased Raynaud’s phenomenon
blood flow to fingers) Deep vein thrombosis
PULMONARY Pleural effusions (accumulation of fluid Interstitial fibrosis
around the lungs) Pulmonary HTN
Pneumonia
NEURO CNS lupus Not common
GI Abd. pain Esophagitis
Ulcers
GERD
MUSCLE Joint inflammation (polyarthritis) Arthralgia
Myositis Myositis
OTHER Fever (indicates exacerbation) Fever
Fatigue Fatigue
Anorexia Anorexia
Weight loss Vasculitis
Generalized weakness
Vasculitis
Osteonecrosis (bone necrosis from lack of
oxygen)
- most common in the hip
>> PSYCHOSOCIAL ASSESSMENT
4
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Quizzguru. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.49. You're not tied to anything after your purchase.
