NURS 531 PHARMACOTHERAPEUTICS NOTES/ DOWNLOAD TO SCORE AN A.
12 views 0 purchase
Course
NURS 531
Institution
NURS 531
EXAM 1 Notes
1. More drugs metabolized by CYP3A4 greater than any other P450 enzyme =
increased drug-drug interaction
2. Factors that regulate Css (serum conc), with this ADME is same to check
maintenance dose = increase drug increase Css plasma levels
3. Induction of CYP450 Enzyme >>>...
more drugs metabolized by cyp3a4 greater than any other p450 enzyme increased drug drug interaction
factors that regulate css serum conc
with this adme is same to check maintenance d
Written for
NURS 531
All documents for this subject (4)
Seller
Follow
BrilliantScores
Reviews received
Content preview
EXAM 1 Notes
1. More drugs metabolized by CYP3A4 greater than any other P450 enzyme =
increased drug-drug interaction
2. Factors that regulate Css (serum conc), with this ADME is same to check
maintenance dose = increase drug increase Css plasma levels
3. Induction of CYP450 Enzyme >>> increased # of enzymes, increased intrinsic?
activity increased rate of metabolism = increase metabolic rate >>> decrease
amount of purest? drug
4. IV drug 1st order kinetic Q 3hrs. 9 hrs later Cp (plasma conc) = 3mcg/L. What was
initial Cp of drug? = 9 hrs = 3 (t1/2 - half life) x 2=6; 6 x2=12 (2nd half life); 12x2=24
(1st half life)
5. Drug A 80% plasma protein bound w/ very low therapeutic index, Drug B 99%
plasma protein = the risk of ADReaction will be more/increased w/ Drug A. So
lower the % the higher the ADR risk
6. Basic (alkalinic) Drug Z pKa (pH) 8.0. not metabolized, undergoes renal elimination
= True statement - acidification of urine will increase renal elimination/excretion of
Drug Z
7. Presence of good slows reabsorption of Antibiotic Tab = a &b (decreases rate of
absorption of Antibiotic; Takes longer to reach Therapeutic plasma levels of
Antibiotics
8. BEST measure of Total amount of oral drug in plasma over time = AUC (area under
the curve)
9. 10mg “LOWOUCH” IV for pain f=0.2, PO amount needed = 10/0.2= 50mg ****PO
amt always > IV amt for same drug
10. Renal clearance of 4 days: 0.90, 0.03, 0.62, 0.18, shortest t1/2(half life) = 0.90
L/hr/kg
11.
EXAM 2 Notes
Module/Exam 2
Weeks 4-6
ANS Quiz
NURS 531 Pharm
Endocrine/Autonomics:
· stion 1
0.2 out of 0.2 points
Among the regimens listed below using various insulin preparations delivered subcutaneously by injection but not by
pump, which would be the most logical?
, Selected Answer: b.
Glargine to provide basal insulin coverage and aspart given before each
meal.
Answers: a.
Lispro to provide basal insulin coverage and detimir given before each
meal.
b.
Glargine to provide basal insulin coverage and aspart given before each
meal.
c.
Detemir to provide basal insulin coverage and NPH insulin before each
meal.
d.
Lispro or glargine injected every 3 hours and NPH given at bedtime.
· Question 2
0.2 out of 0.2 points
Mr. P self-medicates with an aluminum hydroxide antacid before every meal to reduce symptoms of hyperacidity.
However he tends to overeat and drink. As a result, he ends up taking a couple of aspirin every day. Which of the
following is likely to be TRUE with regard to Mr. P’s self-medication with these over-the-counter medications?
Selected c.
Answer: Mr. P. will experience reduced therapeutic effects from the antacid because he is not taking it
at the optimal time.
Answers: a.
More aspirin will be absorbed in the presence of the antacid.
b.
Mr P. is likely to experience diarrhea.
c.
Mr. P. will experience reduced therapeutic effects from the antacid because he is not taking it
at the optimal time.
d.
Mr. P. sometimes takes other types of antacids because one antacid is the same as another
with regard to adverse effects.
· Question 3
0.2 out of 0.2 points
Which of the following statement(s) is/are TRUE about treatment of erectile dysfunction with a
phosphodiesterase type 5 inhibitors? (Hint:You may choose more than one answer.)
, b.
Phosphodiesterase type 5 inhibitors decrease the degradation of cyclicGMP.
c.
Among the phosphodiesterase type 5 inhibitors, tadalafil has the longest half-life.
d.
Use of phosphodiesterase type 5 inhibitors can result in visual disturbances and hypotension
because these inhibitors are not absolutely selective for the phosphodiesterase type 5 isoform.
Answers: a.
Phosphodiesterase type 5 inhibitors stimulate nitric oxide synthase.
b.
Phosphodiesterase type 5 inhibitors decrease the degradation of cyclicGMP.
c.
Among the phosphodiesterase type 5 inhibitors, tadalafil has the longest half-life.
d.
Use of phosphodiesterase type 5 inhibitors can result in visual disturbances and hypotension
because these inhibitors are not absolutely selective for the phosphodiesterase type 5 isoform.
e.
Only sildenafil can be taken with an organic nitrate.
· Question 4
0.2 out of 0.2 points
Anna is an APN is treating a 58 year-old postmenopausal patient for severe osteoporosis. Consider the following and
select one answer.
e.
All of the above actions are incorrect.
Answers: a.
Anna prescribes 2 drugs. She prescribes alendronate and raloxifene because the mechanism of alendronate is
anabolic and the mechanism of raloxifene is anti-resorptive.
b.
Anna suggests that her patient should eat a large meal before taking alendronate to reduce potential
gastrointestinal side effects of the drug.
c.
Anna orders liver function test for 6 months and 12 months after initiating therapy to treat osteoporosis
because bisphosphonates are metabolized in the liver where they form a reactive metabolite that can injure
liver cells.
d.
Because bisphosphonates can cause hypercalcemia, Anna suggests that her patient should refrain from
drinking milk or eating foods like yogurt and ice cream.
e.
All of the above actions are incorrect.
, · Question 5
0.2 out of 0.2 points
Match the mechanism of action with the drug
o
Question Correct Match Selected Match
Glyburide e. e.
Stimulates insulin secretion by binding to beta-cell Stimulates insulin secretion by binding to beta-cell
sulfonylurea receptor sulfonylurea receptor
Pioglitazone a. a.
Act as a PPAR-gamma agonists to reduce insulin Act as a PPAR-gamma agonists to reduce insulin
resistance resistance
Metformin d. d.
Delays glucose absorption from gut, reduces Delays glucose absorption from gut, reduces
gluconeogenesis, reduces glycogenolysis, facilitates gluconeogenesis, reduces glycogenolysis, facilitates
insulin-mediated glucose utilization insulin-mediated glucose utilization
Acarbose c. c.
Delays the absorption of glucose from the intestines Delays the absorption of glucose from the intestines
by inhibiting glucosidase in the wall of the by inhibiting glucosidase in the wall of the
intestines intestines
o
o
All Answer Choices
a.
Act as a PPAR-gamma agonists to reduce insulin resistance
b.
Synthetic GLP-1 mimetic - enhances glucose-dependent insulin secretion, suppresses inappropriately elevated serum
glucose concentrations, and delays gastric emptying
c.
Delays the absorption of glucose from the intestines by inhibiting glucosidase in the wall of the intestines
d.
Delays glucose absorption from gut, reduces gluconeogenesis, reduces glycogenolysis, facilitates insulin-mediated
glucose utilization
e.
Stimulates insulin secretion by binding to beta-cell sulfonylurea receptor
· Question 6
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller BrilliantScores. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $15.49. You're not tied to anything after your purchase.
