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NURS 6521 week 6_Complete Answered Solution guide; Fall 2022. Chapter 11, "Basic Principles of Neuropharmacology" (pp. 67-71) Chapter 12, "Physiology of the Peripheral Nervous System" (pp. 72-81) Chapter 12, "Muscarinic Agonists and Cholinesterase Inhibitors" (pp. 82-89) Chapter 14, "Muscarinic...

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NURS 6521 week 6_Complete Answered Solution
guide; Fall 2022.
Chapter 11, "Basic Principles of Neuropharmacology" (pp. 67-71) Chapter 12, "Physiology of the
Peripheral Nervous System" (pp. 72-81) Chapter 12, "Muscarinic Agonists and Cholinesterase Inhibitors"
(pp. 82-89) Chapter 14, "Muscarinic Antagonists" (pp. 90-98) Chapter 15, "Adrenergic Agonists" (pp. 99-
107) Chapter 16, "Adrenergic Antagonists" (pp. 108-119) Chapter 17, "Indirect-Acting Antiadrenergic
Agents" (pp. 120-124) Chapter 18, "Introduction to Central Nervous System Pharmacology" (pp. 125-
12…

_______ can be defined as the study of drugs that later processes controlled by the
nerovus sytem
✓- neuropharmacology

two basic steps of of neuropharmacologic drugs....
✓- axonal conductionand synaptic conduciton

two influence a process under neuronal control, a drug can alter one of two basic
neuronal activities...
1)
2)
✓- 1) axonal conduction
2) synaptic transmission

is axonal coonduction very selective?
✓- no

drugs that alter synaptic transmission can produce effects that are _______( highly or
minimally?) selective?
✓- highly

the ability of a neuron to influence the behavior of another cell depends untilamtely on
what?
✓- the ability of the neuron to alter receptor activity on the target cell

T or F. the effect of a drug on a neuronally regulated process is dependent on the ability
of that drug to directly or indirectly influence receptor activity on target cells.
✓- TRUE very important

for synaptic transmission to take Place alce, molecules of transmitter must be present in
the ________ _______?
✓- nerve terminal

what is the first step of transmission for neuro drugs?

,✓- transmitter synthesis

what is the second step of transmitter storage?
✓- transmitter storage

what is step 3 of synaptic transmission?
✓- transmitter release

transmitter release is triggered by the arrival of an ______ _____-
✓- action potential

after release, transmitter molecules _______ across the synaptic gap and then undergo
reversible binding to receptors ton the postsynaptic cell
✓- diffuse

the 5th step in transmitter release is when the transmission is terminated by dissociation
of transmitter from its receptor, followed by removal of a free transmitter from the
synaptic gap ✓-

transmitter can be removed fomr the synaptic gap by three processes
1
2
3
✓- 1 reuptake
2 enzymatic degradation
3 diffusion

in synapses where the transmitter is cleared by enzymatic degradation, the synapse
contains large quantities of transmitter-inactivating _______
- ✓- enzymes

all neuropharmacologic agents, produce their effects by directly or indirectly altering
__________ _________.
✓- receptor activity

T or F receptor activtoin can make a process only go faster?
✓- FALSE it can mek it go faster or slower

there are 3 different effects that drugs are known to have on. transmitter synthesis
✓- 1 increase transmitter synthesis
2 decrease transmitter synthesis
3 cause the synthesis to transmitter molecules that are more effective than the natural
transmitter itself

, a drug that increases transmitter synthesis will cause receptor activation to ( INCREASE
OR DECReASE)?
✓- increase

release of "super" transmitters will cause recepto ractivaiton to ________
✓- increase

drugs that interefere with transmitter storagfe will cause the receptor activation to (
INCREASE OR DECREASE)?
✓- decrease

drugs either promote or inhibit transmitter release, amphetamines are examples of
drugs that represent
✓- promoting transmitter relsease

drugs that omhibit relsease will ______ receptor activation
✓- reduce

drugs that directly activate receptors are called ______
✓- agonists

drugs that prevent receptor activation are called ______
✓- antagonists

do morphine, insulin and epinephrine bind directly to the receptor and cause activation?
✓- yes

drugs like naloxone, antihistamines and metoprolol bind directly to receptors and
prevent activation, True or false?
✓- true

Benzodiazepines are an excellent example of a drug that binds to receptors and
________ the actions of a natural transmitter.
✓- enhance

T or F. Drugs can interfere with the termination of transmitter action by two
mechanisms:
1 blockade of transmitter reuptake
2inhibtion of transmitter degradation
✓- true

what is one of the most desirable qualities a drug can have?
✓- selectivity

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