NR 565 / NR565 Advanced Pharmacology Midterm Exam Review| Chamberlain College
1. Typical Antipsychotics
- A class of older drugs to treat schizophrenia and related psychotic disorders primarily by reducing excess levels of dopamine in the brain
- do not give to elderly, neuroleptic mali...
- The most common group of antianxiety drugs, increases GABA and
decreases neuronal excitation
- do not mix with cns depressive agents
- Valium, xanax, ativan
5. Serotonergic anxiolytics
- Enhances serotonin to relieve anxiety
- No CNS depression, no anticonvulsant properties, very mild SE
- Buspirone, ipsapirone, gepirone
6. Barbiturates
- drugs that depress the activity of the central nervous system, reducing
anxiety but impairing memory and judgment, treat epilepsy, seizures,
insomnia
- do not suddenly discontinue, CNS depression does occur, decreases many
other medications such as beta blockers
- pentobarbital, -barbital etc
7. sedative-hypnotics
- Drugs that can act in the body either as sedatives or as hypnotics, depress the
CNS
, 8. Benzodiazepine hypnotics
- Diazepam, Midazolam, Zolazepam
- Potentiates the inhibitory action of GABA. Activation of the receptor causes
an influx of Cl- ion movement into the neuron and hyperpolarization and
inhibition of membrane depolarization
- Addicting
9. Nonbenzodiazepine hypnotics
- Zolpidem, Zaleplon, exZopiclone. "ALL ZZZs put you to sleep."
- MOA: act via BZ1 subtype of GABA receptor. Effects reversed by
flumazemnil
- Use: insomnia
- SE: ataxia, headaches, confusion. Short duration. Decreased depdence risnk
like bneozs and only modest daf-after pscyhomoter depression
10. mood stabilizers
- drugs used to control mood swings in patients with bipolar mood disorders
11. Lithium
- Inhibits IP3 second messenger cascade, mood stabilizer for bipolar
- therapeutic range 0.6 to 1.5
- causes congenital malformations
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