Summary
UofT BCH210 Enzymes Summary
- Course
- Institution
summary of major enzymes covered in metabolism section of BCH210 (taught by Dr. Patterson); includes enzyme function, localization, regulation
[Show more]
Seller
Follow
yuxmil
Content preview
HORMONE SIGNALLING PATHWAYSEnzyme Type of Reaction involved in Activation Inhibition Area in body
enzyme
Creatine kinase Transferase Use of phosphocreatine to Muscles
generate ATP
Glycogen Transferase Glycogenolysis -phosphorylation of Ser14 -dephosphorylation by Muscles + liver
phosphorylase (GP) -generate G1P from -AMP/low energy PP-I
non-reducing ends of (allosteric) -ATP/high energy
glycogen (allosteric)
-G6P (allosteric)
Phosphoglucomutase Isomerase Conversion of G1P into G6P, -phosphorylation of Ser Muscles + liver
or vice versa
G-6-phosphatase Transferase Removal of phosphate from Liver
G6P (hydrolysis) to store
glucose
Protein phosphatase I Transferase Insulin signalling -insulin binding All cells
(PP-I) -inactivates GP, activates GS
UDP-glucose Transferase Conversion of G1P into All cells
pyrophosphorylase UDP-glucose
Glycogen synthase I Addition of glucose (from -dephosphorylation by PP-I -phosphorylation by All cells
(GS) UDP-glucose) onto glycogen -inactivation of GSK3 (via GSK3
insulin binding)
-G6P (allosteric)
, PDC
Enzyme Type of enzyme Reaction involved in Activation Inhibition Area in body
PDC Complex -conversion of pyruvate into -dephosphorylation -phosphorylation
(E1, E2, E3) Acetyl CoA -NADH, Acetyl CoA
Mitochondria
PDC kinase Transferase -turns OFF PDC -NADH, Acetyl CoA -pyruvate, ADP
(allosteric) (allosteric)
PDC phosphatase Transferase -turns ON PDC -Ca2+
CAC
Enzyme Type of enzyme Reaction involved in Activation Inhibition Area in body
Citrate synthase CAC step 1 -ADP, pyruvate -ATP, NADH, citrate Mitochondria
(CS) -formation of citrate from
oxaloacetate + Acetyl CoA
Isocitrate Oxidoreductase CAC step 3 -ADP, Ca2+ -ATP, NADH Mitochondria
dehydrogenase -conversion of isocitrate to
(ICDH) alpha-ketoglutarate
-NADH + CO2
Alpha-ketoglutarate Oxidoreductase CAC step 4 -Ca2+ -ATP, NADH Mitochondria
dehydrogenase -conversion of -succinyl CoA (product
(a-KGDH) alpha-ketoglutarate to inhibition)
succinyl-CoA; NADH + CO2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller yuxmil. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79202 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now