ACRN STUDY SET QUESTIONS AND ANSWERS
2021/2022
Lipoatrophy, the subcutaneous fat wasting of the face and buttocks, is believed to be caused by
which of the following antiretroviral medication?
- Tenofovir alafenamide (TAF)
- Tenofovir (TDF)
- Abacavir (ABC)
- Zidovudine (ZDV) Correct Answers: Zidovudine (ZDV)
Proximal renal tubulopathy and elevated creatinine are an adverse event related to the use of what
antiretroviral medication?
- Tenofovir (TDF)
- Tenofovir alafenamide (TAF)
- Triumeq (ABC+3TC+DTG)
- Dolutegravir (DTG) Correct Answers: Tenofovir (TDF)
If a person with HIV infection has painless flesh-colored papules over the face and neck, which of the
following dermatological conditions should be suspected?
- Molluscum contagiosum
- Psoriasis
- Kaposi's sarcoma
- Seborrhea Correct Answers: Molluscum contagiosum
What adverse event is related to the use of Abacavir?
- Myocardial infarction, ischemic stroke
- Central nervous system/neuropsychiatric symptoms
- Dyslipidemia
- Cardiac QTc interval Prolongation Correct Answers: Myocardial infarction, ischemic stroke
You have a patient who newly diagnosed with HIV and HCV. She tells you that she is interested in
pursuing treatment for HCV immediately as she has a friend who experienced complications from the
disease. Which circumstance would most strongly warrant the deferment of HCV treatment for this
patient?
- Your patient's CD4 is <200 cells/mm3
- Your patient is an active intravenous drug user
- Your patient is on opiod substitution therapy (OST) (methadone/buprenorphine) and you are
concerned about potential drug-drug interactions
- Your patient has advanced liver fibrosis Correct Answers: Your patient's CD4 is <200 cells/mm3
Rationale: Improved immune status should be the priority for patients with a CD4 count below 200
cells/mm3. Research shows us that patients with active substance abuse do not have worse rates of
, SVR as compared to patients without active substance abuse. However, these patients will likely
need increased support and adherence follow up. There are not significant drug-drug interactions
between DAAs and OST. References: U.S. Department of Health and Human Services. 2017.
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV:
Considerations for Antiretroviral Use in Patients with Coinfections.
Your patient, who is co-infected with HIV/HBV, wants to know if she can start taking what she heard
is the "newer, safer" version of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF),
instead. You explain:
- TAF is not currently FDA approved for the treatment of HBV
- TAF is currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is not currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is currently FDA approved only for PrEP Correct Answers: TAF is currently FDA approved for
the treatment of HIV/HBV coinfection
Rationale: While switching from TDF to TAF is acceptable and preferable in many cases, per DHHS
guidelines (2017), discontinuation of ART with anti-HBV activity may cause serious hepatocellular
damage resulting from reactivation of HBV. Therefore, DHHS recommends that patients should be
advised against stopping these medications and be carefully monitored during interruptions in HBV
treatment. References: U.S. Department of Health and Human Services. 2017. Guidelines for the
Use of Antiretroviral Agents in Adults and Adolescents Living with HIV: Considerations for
Antiretroviral Use in Patients with Coinfections.
What antiretroviral therapy needs to be taken with a meal containing 400 calories or more?
- Atripla
- Triumeq
- Stribild
- Complera Correct Answers: Complera
Hypersensitivity reaction, or Stevens-Johnson syndrome, is an adverse event which can occur in an
HLA B 5701+ patient taking which antiretroviral?
- Efavirenz (EFV)
- Abacavir (ABC)
- Lamivudine (3TC)
- Dolutegravir (DTG) Correct Answers: Abacavir
Which of the following is the first priority when admitting a patient suspected of having Mycobacterium
tuberculosis?
- Perform PPD testing
- Initiate airborne isolation
- Obtain chest X-ray
- Collect sputum for acid-fast bacillus Correct Answers: Initiate airborne isolation
A woman who is HIV-positive tells the nurse that she is considering becoming pregnant and wonders
if her baby will be infected. Which of the following is the most appropriate response by the nurse?
2021/2022
Lipoatrophy, the subcutaneous fat wasting of the face and buttocks, is believed to be caused by
which of the following antiretroviral medication?
- Tenofovir alafenamide (TAF)
- Tenofovir (TDF)
- Abacavir (ABC)
- Zidovudine (ZDV) Correct Answers: Zidovudine (ZDV)
Proximal renal tubulopathy and elevated creatinine are an adverse event related to the use of what
antiretroviral medication?
- Tenofovir (TDF)
- Tenofovir alafenamide (TAF)
- Triumeq (ABC+3TC+DTG)
- Dolutegravir (DTG) Correct Answers: Tenofovir (TDF)
If a person with HIV infection has painless flesh-colored papules over the face and neck, which of the
following dermatological conditions should be suspected?
- Molluscum contagiosum
- Psoriasis
- Kaposi's sarcoma
- Seborrhea Correct Answers: Molluscum contagiosum
What adverse event is related to the use of Abacavir?
- Myocardial infarction, ischemic stroke
- Central nervous system/neuropsychiatric symptoms
- Dyslipidemia
- Cardiac QTc interval Prolongation Correct Answers: Myocardial infarction, ischemic stroke
You have a patient who newly diagnosed with HIV and HCV. She tells you that she is interested in
pursuing treatment for HCV immediately as she has a friend who experienced complications from the
disease. Which circumstance would most strongly warrant the deferment of HCV treatment for this
patient?
- Your patient's CD4 is <200 cells/mm3
- Your patient is an active intravenous drug user
- Your patient is on opiod substitution therapy (OST) (methadone/buprenorphine) and you are
concerned about potential drug-drug interactions
- Your patient has advanced liver fibrosis Correct Answers: Your patient's CD4 is <200 cells/mm3
Rationale: Improved immune status should be the priority for patients with a CD4 count below 200
cells/mm3. Research shows us that patients with active substance abuse do not have worse rates of
, SVR as compared to patients without active substance abuse. However, these patients will likely
need increased support and adherence follow up. There are not significant drug-drug interactions
between DAAs and OST. References: U.S. Department of Health and Human Services. 2017.
Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV:
Considerations for Antiretroviral Use in Patients with Coinfections.
Your patient, who is co-infected with HIV/HBV, wants to know if she can start taking what she heard
is the "newer, safer" version of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF),
instead. You explain:
- TAF is not currently FDA approved for the treatment of HBV
- TAF is currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is not currently FDA approved for the treatment of HIV/HBV coinfection
- TAF is currently FDA approved only for PrEP Correct Answers: TAF is currently FDA approved for
the treatment of HIV/HBV coinfection
Rationale: While switching from TDF to TAF is acceptable and preferable in many cases, per DHHS
guidelines (2017), discontinuation of ART with anti-HBV activity may cause serious hepatocellular
damage resulting from reactivation of HBV. Therefore, DHHS recommends that patients should be
advised against stopping these medications and be carefully monitored during interruptions in HBV
treatment. References: U.S. Department of Health and Human Services. 2017. Guidelines for the
Use of Antiretroviral Agents in Adults and Adolescents Living with HIV: Considerations for
Antiretroviral Use in Patients with Coinfections.
What antiretroviral therapy needs to be taken with a meal containing 400 calories or more?
- Atripla
- Triumeq
- Stribild
- Complera Correct Answers: Complera
Hypersensitivity reaction, or Stevens-Johnson syndrome, is an adverse event which can occur in an
HLA B 5701+ patient taking which antiretroviral?
- Efavirenz (EFV)
- Abacavir (ABC)
- Lamivudine (3TC)
- Dolutegravir (DTG) Correct Answers: Abacavir
Which of the following is the first priority when admitting a patient suspected of having Mycobacterium
tuberculosis?
- Perform PPD testing
- Initiate airborne isolation
- Obtain chest X-ray
- Collect sputum for acid-fast bacillus Correct Answers: Initiate airborne isolation
A woman who is HIV-positive tells the nurse that she is considering becoming pregnant and wonders
if her baby will be infected. Which of the following is the most appropriate response by the nurse?
