Deze samenvatting bevat hoofdstuk 9 uit het handboek. Het gaat over de celcommunicatie en alle processen die hiermee te maken hebben. Deze processen worden beknopt uitgelegd en zijn de basis van de celcommunicatie.
Signaling molecule binding site = Celopp. Transmembraan receptor
• Energierijk GTP bindt erop
• G proteïne = similar structure
• GPCR = extreem breed & divers in functie
• Adrenaline bindt erop
Segment that
interacts with
G proteins inside the cell
Figure 9.8b
G protein-coupled receptor
G proteien in het G protein-coupled Plasma membrane Activated Signaling
receptor receptor molecule
membraan, altijd samen
ducation Ltd.
in de buurt
(=dominosteentjes) GDP GTP
G protein Inactive
GDP GTP
(inactive) Enzyme enzyme
Als weinig molecule è 1 2
heel snel terug omgezet Activated EXTRACELLULAR
enzyme
in GDP & terug inactief
(heel snel activeren/ uit/
activeren/ uit…) (alleen GTP GDP
iets nodig voor activatie, P
i
Cellular
uit = automatisch) response CYTOPLASM
3 4
Cellular
P Tyr Tyr P
Tyr Tyr P Tyr Tyr P response 1
P Tyr Tyr P
Tyr Tyr P Tyr Tyr P
P Tyr
Tyr Tyr
6 ATP 6 ADP
P Tyr Tyr P
Tyr P Cellular
response 2
Activated tyrosine Fully activated receptor
kinase regions tyrosine kinase
(unphosphorylated (phosphorylated Inactive
dimer) dimer) relay proteins
• In membraan (=monomeren)
Hebben receptorsite & zitten altijd per 2 (altijd inactief)
• Signaalmolecule komt è gaan ze samen è dimeer gevormd
è fosforyleren è receptor eiwit geactiveerd
• Verschil met G: meerdere responsen tegelijk op gang gebracht
• Kinase zet P van op ATP op een ander molecule (Meestal hydroxyl groep)
Kanaalproteïne = afgesloten
Ligand bindt è open
Ionen (Ca, Na..) kunnen
door
Sluit terug
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