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Cell Biology 2016 Exam Paper
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Cell Biology 2016 Exam Paper
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IMPERIAL COLLEGE LONDONB.Sc. Examination 2016
This paper is also taken for the relevant examination for the Associateship of the Royal
College of Science
INTEGRATIVE CELL BIOLOGY
Thursday 16 June 2016 10.00 - 13.00
FOR SECOND YEAR STUDENTS IN BIOCHEMISTRY AND BIOTECHNOLOGY
Answer any FOUR questions. Answer each question in a separate book. Parts of a
question carry equal weighting unless otherwise specified.
1. How does ligand binding to a G protein-coupled receptor change the levels of
cyclic AMP in the cell? How can cAMP mediate fast and transient responses, as
well as slow and sustained responses?
2. Explain why the small GTPase Ras is a proto-oncogene.
3. Discuss the evidence that many cases of Alzheimer’s disease and Parkinson’s
disease are caused by prion-like mechanisms.
4. Discuss theories of how memories form in the hippocampus.
5. What are embryonic stem cells? (30%) What are induced pluripotent stem cells?
(30%) Discuss the reasons why it might be important to continue to investigate
the biology of embryonic stem cells. (40%)
6. What is a stem cell niche? (30%) With reference to skeletal muscle and/or the
gut, discuss the roles that the niche can play in regulating stem cell behaviour.
(70%)
7. Describe the process of lymphocyte activation by antigen in lymph nodes.
8. How do the products of the MHC influence the ability of an individual to initiate an
immune response?
End of paper
© Imperial College London
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