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Lecture 2 Oncogenesis; Hallmarks of Cancer
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Hallmarks of cancer, invasion, metastasis, evading apoptosis, etc
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Src = sarc/sarcoma. This src gene is highly similar to the human gene for a protein kinase (tyrosine).Proto-oncogenes are normal genes that can become oncogenes by gene mutations / amplification /
translocation / insertional mutagenesis.
Bcr/abl gene is constantly active (fusion protein → chromosomal translocation). Bcr gene on
chromosome 22, abl gene on chromosome 9.
Overexpression of Bcl-2 = anti-apoptotic.
Oncogene = gain of function. Tumor suppressor gene = loss of function.
Retinoblastoma (eye cancer, Rb) controls the cell cycle and it is a tumor suppressor gene. Loss of
function (mutated in both alleles) results in an uncontrolled cell cycle.
Colorectal cancer due to defects in Wnt signalling. B-catenin is an oncogene. If it’s not degraded it
will be present in high numbers. Hereditary mutations in APC (TSG in Wnt signaling pathway) results
in FAP (polyps).
NF-1 deactivates RAS (tumor suppressor gene). Small molecule inhibitors and antibody therapy are
two cancer therapies that are used often lately.
Hereditary cancer: almost exclusively TSG mutations (oncogenic mutations are embryonic lethal).
P53 blocks initiation of DNA synthesis and/or initiates apoptosis and is therefore both an TSG as an
oncogene.
Lecture 2 Hallmarks of Cancer
1. Self-sufficiency of growth signals (sustaining proliferative signalling)
cell proliferation without the need of external growth factors.
2. Insensitivity to anti-growth signals (evading growth-suppressors)
Loss of cadherins or … → Loss of tumor suppressors (2-hit event) → continued proliferation
Anti-growth signals: oncogenic signalling, glucose, DNA damage, ROS, lack of nucleotides.
These signals go through TP53 (tumor suppressor gene P53).
3. Evading apoptosis
Loss of pro-apoptotic proteins and increased survival signals → Survival.
4. Limitless replicative potential
Telomeres are ends of chromosomes. End replication problem. Loss of DNA. Anytime you have a
cell division you’ll lose a bit of your chromosome. Telomere shortening. Eventually you’ll damage
your DNA.
Telomere extension by telomerase. Reverse transcription with a RNA primer. Especially within
germ line cells.
Telomerase reactivation → immortality
5. Sustained angiogenesis
Cancer doesn’t naturally have this. New vessels to the tumour. VEGF is a ligand for a receptor
tyrosine kinase that activates this process. Pro-angiogenic signals → vascularization (formation of
new blood vessels).
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