Summary
Samenvatting Medicinale chemie deel DNA boek 1
- Course
- Institution
Schema medicinale chemie deel DNA boek 1
[Show more]
1 review
By: yolo1234 • 3 months ago
Seller
Follow
Nessie81
Reviews received
Content preview
DNA Rechtstreeks
o Intercalatie: vlakke structuur die past tussen opeenvolgende bp waardoor
lokaal de structuur verandert DNA niet meer herkend door enzymen
DNA vervult functie niet meer
Anthracycline antibiotica: antitumoraal (te toxisch als antibioticum),
structuur: aminoglycoside (in mineure groeve) + vlak gedeelte
Adriamycine/doxorubicine
Chinon: vrije radicalen Daunomycine/daunorubicine
cardiotoxiciteit Dactinomycine: antitumoraal (te toxisch als antibioticum)
Synthetische verbindingen
Amsacrine
Mitoxantrone
Ellipticine
o Binding en doorbraak: vorming vrije radicalen superoxideradicalen, ook
onrechtstreeks
Bacteriële + protozoa infecties (antibiotica)
Nitrofuranen en –imidazolen
o Nitrofurantoine
o Nitrofurazone NO2: activiteit
o Nifurtoinol
Imidazool/furaan: redoxpotentiaal NO2
o Metronidazol
enkel in anaerobe cellen
o Nimorazol
o Tinidazol Subtituenten: redoxpotentiaal
o Ornidazol
Antitumoraal
Anthracyclines
Bleomycine: enkel in aerobe cellen, ook onrechtstreeks, stabiele
vorm (Cu), actieve vorm (Fe)
o Alkylerend: antitumoraal
Direct
2-Haloalkylamines: vorming aziridiniumion intermediair, R-groep
draagt bij tot reactiviteit en oplosbaarheid
o Melfalan
o Estramustine (prostaatcarcinoom)
Methaansulfonaten
o Busulfam: kruisverbindingen
Ethyleenimines
o Thiotepa: 2 manieren van alkyleren
Aryltriazines: aromatische groep met 3 opeenvolgende N
o Dacarbazine: 2 manieren van alkyleren
Enzymatische activatie
Reductie: vaak een chinon
o Mitomycine C: kruisverbindingen
o Anthracyclines
o Camptothecine: kruisverbindingen
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Nessie81. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $5.97. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
62555 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now