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Public-Health-First-Aid-For-The-Usmle-Step-1
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First Aid for the USMLE Step 1 2020, Thirtieth
FA 2019.pdf
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21 pages (109.99 MB)
1/5/20, 12:57:57 PM
1/5/20, 12:52:18 PM
BY u/verified-idiot
To the only girl i've ever loved, to soufia.
BLUE new in FA 2020
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,HIGH-YIELD PRINCIPLES IN
Public Health Sciences
“Medicine is a science of uncertainty and an art of probability.” ` Epidemiology and
—William Osler Biostatistics 256
“There are two kinds of statistics: the kind you look up and the kind you ` Ethics 265
make up.”
—Rex Stout ` The Well Patient 270
“On a long enough timeline, the survival rate for everyone drops to zero.” ` Healthcare Delivery 270
—Chuck Palahniuk
` Quality and Safety 273
“There are three kinds of lies: lies, damned lies, and statistics.”
—Mark Twain
A heterogenous mix of epidemiology, biostatistics, ethics, law, healthcare
delivery, patient safety, quality improvement, and more falls under the
heading of public health sciences. Biostatistics and epidemiology are the
foundations of evidence-based medicine and are very high yield. Make
sure you can quickly apply biostatistical equations such as sensitivity,
specificity, and predictive values in a problem-solving format. Also, know
how to set up your own 2 × 2 tables. Quality improvement and patient
safety topics were introduced a few years ago on the exam and represent
trends in health system science. Medical ethics questions often require
application of principles. Typically, you are presented with a patient
scenario and then asked how you would respond.
255
, 256 SEC TION II PUBLIC HEALTH SCIENCES `P̀UBLIC HEALTH SCIENCES—EPIDEMIOLOGY AND BIOSTATISTICS
``
PUBLIC HEALTH SCIENCES—EPIDEMIOLOGY AND BIOSTATISTICS
Observational studies
STUDY TYPE DESIGN MEASURES/EXAMPLE
Cross-sectional study Frequency of disease and frequency of risk- Disease prevalence.
related factors are assessed in the present. Can show risk factor association with disease, but
Asks, “What is happening?” does not establish causality.
Case-control study Compares a group of people with disease to a Odds ratio (OR).
group without disease. Patients with COPD had higher odds of a
Looks to see if odds of prior exposure or risk smoking history than those without COPD.
factor differ by disease state.
Asks, “What happened?”
Cohort study Compares a group with a given exposure or risk Relative risk (RR).
factor to a group without such exposure. Smokers had a higher risk of developing COPD
Looks to see if exposure or risk factor is than nonsmokers.
associated with later development of disease. Cohort = relative risk.
Can be prospective or retrospective.
Crossover study Compares the effect of a series of ≥2 treatments Allows participants to serve as their own
on a participant. controls.
Order in which participants receive treatments
is randomized. Washout period occurs
between each treatment.
Twin concordance Compares the frequency with which both Measures heritability and influence of
study monozygotic twins vs both dizygotic twins environmental factors (“nature vs nurture”).
develop the same disease.
Adoption study Compares siblings raised by biological vs Measures heritability and influence of
adoptive parents. environmental factors.
Clinical trial Experimental study involving humans. Compares therapeutic benefits of ≥2 treatments, or of
treatment and placebo. Study quality improves when study is randomized, controlled, and double-
blinded (ie, neither patient nor doctor knows whether the patient is in the treatment or control
group). Triple-blind refers to the additional blinding of the researchers analyzing the data.
Four phases (“Does the drug SWIM?”).
DRUG TRIALS TYPICAL STUDY SAMPLE PURPOSE
Phase I Small number of either healthy volunteers or “Is it Safe?” Assesses safety, toxicity,
patients with disease of interest. pharmacokinetics, and pharmacodynamics.
Phase II Moderate number of patients with disease of “Does it Work?” Assesses treatment efficacy,
interest. optimal dosing, and adverse effects.
Phase III Large number of patients randomly assigned “Is it as good or better?” Compares the new
either to the treatment under investigation or treatment to the current standard of care (any
to the standard of care (or placebo). Improvement?).
Phase IV Postmarketing surveillance of patients after “Can it stay?” Detects rare or long-term adverse
treatment is approved. effects (eg, black box warnings). Can result in
treatment being withdrawn from Market.
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