Receptor
Macromolecule whose biological function changes when a drug binds to it
What are the link between chemical actions and biological function?
Receptors
Emax
maximum effect of a drug
What happens when Emax is reached?
Emax occurs when all receptors are bound
Wh...
CPPS 304
Receptor correct answerMacromolecule whose biological function changes when a drug binds to it
What are the link between chemical actions and biological function? correct answerReceptors
Emax correct answermaximum effect of a drug
What happens when Emax is reached? correct answerEmax occurs when all receptors are bound
What is in indication that spare receptors are present? correct answerWhen Emax is reached before all receptors are bound
Agonist correct answerhas affinity for a receptor as well as intrinsic activity at the receptor
Antagonist correct answerhas affinity for a receptor but no intrinsic activity at the receptor
partial agonist correct answerhas affinity for a receptor but lacks the full intrinsic activity of an agonist
inverse agonist correct answerbinds to a constitutively active receptor and inactivates it
affinity correct answerthe propensity of a ligand to bind to a receptor
high affinity = correct answerbinds readily to a receptor
low affinity = correct answerspends less time bound to a given receptor
intrinsic activity correct answerthe action carried out by the ligand while it is bound to a receptor Kd correct answerdissociation constant (affinity of a drug for a receptor)
What does the value of Kd signify? correct answermeasures the propensity of a drug to release (dissociate) from a receptor
What does a high Kd mean? correct answerdrug readily dissociates from its receptor
What does a low Kd mean? correct answersuggests high affinity for its receptor
If a patient were to overdose on a reversible antagonist, what could you do? correct answerAdd more agonist
Irreversible or Non-Competitive Antagonists correct answerbind to receptor for life
Reversible or Competitive Antagonists correct answerbind and release from a receptor and are in a constant state of flux
True or False, increasing the concentration of agonist will overcome the effects of an irreversible antagonist. correct answerFalse
What are the four types of receptors? correct answerIon channel, G-protein coupled, Coupled to enzymes, Intracellular
What type of receptor involves Acetylcholine? correct answerIon channel
What is the fastest type of receptor? correct answerIon channel
What type of receptor involves adrenergics like epinephrine? correct answerG-protein coupled
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