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Summary Pharmacology Rapid Revision Krok 1 $3.20
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Summary Pharmacology Rapid Revision Krok 1

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In this file you will find a Rapid Revision Summary by Medic Mukul, for the Pharmacology part of Krok 1. A part of the summary is based on most frequent asked questions as well as ministery questions.

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  • May 2, 2023
  • 7
  • 2022/2023
  • Summary

1  review

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By: harmdhal • 2 months ago

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Pharmacology

Rapid Revision KROK I




@ Medic Mukul
Minna Mamik

, Minna Mamik

Metzonidade Antibioties, Antihelminths, Antiparasitic
=
Actozolamine =

Divadics acts on
pct (proximal convulated
Anaerobic infection Tubules(
Carbonic
↳MOA-Inhibit
anhydrase (cofecta -
2nit)

->
Amebiasis, Lambliasis, Giardia ↳ Cause -
Maximum
Hypokatemia (decrease kt)
Used fa Helicobact. ↳ DOC-Mountain
Pyloi Sickness
->



(Microderophilic= inlow 02)


Disulfizam & Metzonidazde -> Blocks
Actaldehyde Furasemide- AKA Lasix

dehydrogenese ↳ Forceddivities
↳ Alcohol metabol.
act
on Loop of Henke (Ascending (ocp
Levomycetin=
Beoad Spectrum Antibiotics ↳ Used fa pulmonary Edema




Fransbang
AKA Ginhibits Sos Ribosomal Unit) ↳
chlorampheniod
t
mg2, t(art,tkt


omeen
Effect;Bone
->
Side Marrow Suppresion
Caet
(S/E) Grey Baby Syndrome





↳hypoplastic Anemia
-skin
H,
lungs
Histamine Thiazide

FantamiBlock
ne
-> Diledic act on DCT
-
Hz Stomach
He Reapta vasocialeen
-




-




H ->
e.g Hydrochloodhiazide, Clopamide (4cart)
permeability

vascular
(ptin stomach)
->
causes
Bronchoconstructu Metabolic
-> used
for
Alkalosis
C H I C
CLoose H+)
/Avil
Congestive Hype-Insipidus Calculi

Diphenyl hydramine
I
Dimedro / Heart Tension (Diabet)
I

calcium
↑st Generation H, Blocken Failure
Cemastin


S
S/E-Sedation (moe
Tavegil ↳
Supzastin
Sleep) Neven
give with
Digioxin

Give Loadidine-2ndG. Potassium
Sparing Divatics -> Acton Collecting duct


3rd-No sedation Citzizine less Sedative. 1) Spizinolactone Antagonistof
=
Aldostenone

↳ Levo -Citzzine & Des-losatidine ->
used for CONN' Syndrome
->
Best for CHF

hyperaldostenonism
↳ * Nat ↑
cat
kt
S/E-Gynecomastia

->




Succinyl Chdine AKA
=




Didhylinum a Listenone 2) Eplizenon - cause
doesn't
Gynecomastia
(non-competitive/izreversible)
4
Depolarising Muscle Relaxant (shatpa). I potasium sparing Davetics
↳ La Tracheal
I
Used Indubation A
-
Amiloride


inhibited Spizinolactone
by pseudocholinestease S -
or

Tx Blood
=


(geneticallypt)
Transfusion Butyryl Cholinestate + -
Triametzine

Note:Acetylcholine inhibited by Aadylcholinestenase
=
E -


Eplizenone
(NAfor (NS)


Anti-arrythmic Drugs
Curanium (Revensible)
Muscle Relaxant Nat blocken ClassI Anti-arythmic Dzugs

E
-




Non-depolarizing Dzocainamide ->


class I ↳ SIE-SLE (systemic Lupus Ezythematous
↳ mechanis of Action;Binds to heuromic Receptas of CNat
(MM0A)
parasymp.Cflaccid paralysis)
Myastemia -
in Muscle
Result
Lading Blocke) Lidocai -> Both Anesthetic aswell as Avrythmic
procain
Doc faMI & Digoxin toxicity
Gavis
->
induced VT
novocain

↳Antidote
Audoimmune
disorder (Drug of CHoise)
-




Neostigamin
(adnozecptas)

I Mepse or
-> Beta Blockens

Class I symp.
-> DOC fa Atrial fibzillation/Atzial Flut

, Minna Mamik
class I
[Amiodzone ->
longestadding A-arythmic Opoids
MOA:Ktchannel
by Natural opoids:Morphine
->
Blocken,
prolong Repolarisation codeine

Moscapine

Class
(Butiazem cantchannel Black herag en Semi Synthetic -> Heroine (Diacetylmaphine)
Stable Angina
Synthetic opoids ->
Fentaryl -> loox
m ore powerfull then maphine
Calcium Channel Blockus function of uses:
in
Epilepsy abnormal Neucoleptic Anal gesia
↳ Brain du do GABA
Sodium Anaesthesia
1) Valpzoate
-Cart channel+Nat channel Blockers Opoid Agonist -> acton opoid Recepta
killer
GABA -> pain

inhibits neurot. , ↑ GABA
by inhibiding its metabolism Morphine->Analgesic fa Seven pain (Labour, cance, MI)
use for kids
can't
↳4 Histamine
- ist line
drug fa Epilepsy (Scizures) zelease


>DOC -



Myoclonic Seizures codeine -> Antitussive (Mild to Moderate
cough) -> Nacotic


I have teratogenic effect (MC SIE-nausea/(

Analgesic
vomitting


2) Ethouxamide -> Cat channel Blockus Tramadol /Peomedol -> Mild do moderate pain (Analgesic
↳ children
>DOC -




Typical Absence Seizures (hanoctic)
↳ staring at
space, confusion
SIE-SLE (toxic to (NS) & like
given to kids
morphine Tramadol
> same
drug -




Nat channel Blockers Opoid Antagonist (Antidot)

fa Neuropathic Pain Naloxon (Shotest Acting)
1) phenytoin -> DOC ->




2) Carbamazepine->DOC La partial Seizures/Teigeminal ->
Nalmefene (Short Act.)
Neuialgia
3)
Lamotrigine ->2nd line
for Absence Seizures ->
Naltzxone (Longest Acting)
>No action on GABA Release


Safe Lithium
in
pregnancy - DOC in
prophylaxis of Mania Bipdan disaden


Topicamate Levodopa La
Parksonextebeamidal disea
4) -> Nat + blocken
kt Carbedopa-> used



Sedative
Hypnotics - cause
sleeping/Tranqualizus Typical Anti-psychotics -> Neuroleptic
/Bradykines"in e

Rigisty
Trema
Benzodiazepines- longest acting B2D; >MOA- Blocks Dopamine -
2 Recepten
Dopamine,



loss of neue c
Diazepam - Muscle Relax., Calmin effect t uses -




Schizopheria (and line)
in substantia
fa Alcohol withdraw.
a
used

Clonazepam -DOC Absent
Seizures & Huntington's Nigla
infantile spasm Hallucinations
shortest
acting Midozolam (beliefs thata re
2
B2D ->
Psychosis Delusions
true/inati
ThoughtDisaden
shot Laazepam fa status Neuroleptic Ami
acting B2D

~
-> -




Hallucination
-




Epilepticus
↳ Antidote:Flumazenit Schizophenia (ministery G1 -
soo)
Hundigton's challa



>Barbiturates -



e.g phenobarbitol (Microsomal inducul Low D2 potency -> Molidone
phenodhiazine -

chlapzomazine
Antidote ->
Bemegside (Aminazine)

Drug Nitzazepam ->
Sleeping Pill High De potency ->
Butyrophenone -

Haloperidol
Desperidol -> Neuroep
analges
S/E -


Hyperpedactinemia,
Extrapyramidal symptoms
↳ Kadhisia - Restlessness

Dzoperidolum -
Neurceptic Analgesia

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