CPPS 304 questions correctly answered to pass 2023

CPPS 304 questions correctly answered to pass 2023Receptor - correct answer Macromolecule whose biological function changes when a drug binds to it What are the link between chemical actions and biological function? - correct answer Receptors Emax - correct answer maximum effect of a drug What happens when Emax is reached? - correct answer Emax occurs when all receptors are bound What is in indication that spare receptors are present? - correct answer When Emax is reached before all receptors are bound Agonist - correct answer has affinity for a receptor as well as intrinsic activity at the receptor Antagonist - correct answer has affinity for a receptor but no intrinsic activity at the receptor partial agonist - correct answer has affinity for a receptor but lacks the full intrinsic activity of an agonist inverse agonist - correct answer binds to a constitutively active receptor and inactivates it affinity - correct answer the propensity of a ligand to bind to a receptor high affinity = - correct answer binds readily to a receptor low affinity = - correct answer spends less time bound to a given receptor intrinsic activity - correct answer the action carried out by the ligand while it is bound to a receptor Kd - correct answer dissociation constant (affinity of a drug for a receptor) What does the value of Kd signify? - correct answer measures the propensity of a drug to release (dissociate) from a receptor What does a high Kd mean? - correct answer drug readily dissociates from its receptor What does a low Kd mean? - correct answer suggests high affinity for its receptor If a patient were to overdose on a reversible antagonist, what could you do? - correct answer Add more agonist Irreversible or Non-Competitive Antagonists - correct answer bind to receptor for life Reversible or Competitive Antagonists - correct answer bind and release from a receptor and are in a constant state of flux True or False, increasing the concentration of agonist will overcome the effects of an irreversible antagonist. - correct answer False