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ASCP MB EXAM STUDY GUIDE
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ASCP MB EXAM STUDY GUIDE /ASCP MB EXAM STUDY GUIDE /ASCP MB EXAM STUDY GUIDE
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ASCP MB EXAM STUDY GUIDE 2023-2024Acute Promylocity Leukemia (APL) - ✔t(15:17)
PML / RARa genes
Chronic Myelogenous Leukemia (CML) - ✔t(9:22)
a.k.a. Philadelphia chromosome
ABL1 / BCR genes
Burkitt's non-Hodkin's Lymphoma - ✔t(8:14)
dysregulation of c-myc gene
breakpoints on ch.8 spread over 190kbp region 5' to 3'
Follicular non-Hodkin's Lymphoma - ✔t(14:18)
IgH / BCL2 genes
Mantle Cell Lymphoma (MCL) - ✔t(11:14)
CCND1 / IgH genes
overexpression of cyclin D1 (cell cycle gene)
MALT Lymphoma
(a.k.a. Marginal Zone) - ✔t(11:18)
API2 / MLT genes
"mucosa-associated lymphoid tissue"
Haploid Genome - ✔3.3 billion bp
Carbamazepine Resistance - ✔HLA B1502
Factor V Leiden - ✔c.1691G>A / p.R506Q
causes Thrombophilia
Cystic Fibrosis mutation - ✔delta F508, 3bp deletion
HERceptin Therapy - ✔HER2+/neu
Overexpression of HER2 receptors causing cancer cells to grow
Vancomycin Resistance (Enterococcus) - ✔van A
MRSA (resistant staph) - ✔mec A
Mycobacterium tuberculosis - ✔katG, inhA
Most cancerous HPV - ✔Strain 16 - 70% of all cases
Graft vs Host Disease - ✔Linked w CMV replication
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