UAMS Hematology Exam #6

PTT - Answer- What is the intrinsic system tested with? PT - Answer- What is the extrinsic system tested by? HMW kininogen and prekalikrein activate the extrinsic, whereas exposed collagen that releases thromboplastin activates the intrinsic pathway. - Answer- What activates the extrinsic pathway? What about the intrinsic pathway? PT and PTT - Answer- What is the common system tested by? 2, 7, 9, and 10 - Answer- What factors are associated with Factor K? 1, 5, 8, 13, and 2 - Answer- What are the consumable factors? Hemostasis - Answer- What is the process of keeping blood in the fluid state unless clotting occurs due to vascular injury? Primary hemostasis is the platelet plug formed on damaged vessels, whereas secondary hemostasis is the fibrin formation from plasma factors. - Answer- What is the difference between primary and secondary hemostasis? To form an endothelial layer and prevent RBCs from escaping. The release of exposed substances such as collagen and Von Willebrands factor causes a break in the system allowing RBCs to escape which causing bleeding and bruising. Vasoconstriction occurs to stop the blood flow. - Answer- What is the role of the vascular system? What causes a break in this system? What puts a stop to this? Bruising, petechiae, and mucous membrane bleeding - Answer- What are the vascular disorder symptoms? Inherited, often hereditary teleangiectasia and acquired, often from drugs such as steroids, estrogen, or just from age - Answer- What are the two categories for vascular disorder? Megakaryocytes, produced in the bone marrow. It is the only cell that gets bigger as it matures. - Answer- What is the parent cell to platelets and where is it produced? What is unique about this cell? Thrombopoietin and CSF - Answer- What influences the number and size of megakaryocytes? Endomitosis, megakaryocytes - Answer- What is the doubling of DNA without cell division? What