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Summary The Mitotic cell cycle

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Compiled and Summarised notes all based on the chapter The mitotic cell cycle and units falling under it, with diagrams included

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AS Bio notes Raida 12D

The mitotic cell cycle

5.1 Growth and Reproduction
 Cells reproduce by dividing and passing on copies of their genes to ‘daughter’ cells
 The process must be very precisely controlled so that no vital genetic information is lost
 The nucleus always divides before a cell divides
 Each of the two daughter cells therefore contains its own nucleus
 This is important because the nucleus controls the cells activities, this is because it
contains the genetic material, DNA, which acts as a set of instructions/code for life
 All the cells in the bodies of multicellular organisms are genetically identical, apart from
the reproductive cells known as gametes
 This is because they all come from one cell, the zygote
 This is the cell formed when one gamete from the mother and one gamete from the
father fuse
 When the zygote starts the process of growth, it divides into two cells with identical
nuclei
 This involves a type of nuclear division called mitosis
 Nuclear division followed by cell division continues to be repeated in a cycle called the
mitotic cell cycle to produce all the cells of your body

5.2 Chromosomes
The structure of chromosomes




 The chromosome at this stage is a double structure
 Made of two identical structures called Chromatids, joined together
 Two identical chromatids of one chromosome are known as sister chromatids
 There are two chromatids because during the period between nuclear divisions,
interphase, each DNA molecule in a nucleus makes an identical copy of itself
 Each chromatid contains one of these DNA copies
 The sister chromatids are held together by Centromere to form a single chromosome
 The centromere could be anywhere along the length of the chromosome
 DNA is the molecule of inheritance and is made up of a series of genes
 Each gene is one unit of inheritance
 The two DNA molecules [one in each of the sister chromatids] are identical

,  This means the gene on the chromatids are also identical
 The fact that there are two identical chromatids is the key to precise nuclear division
 When cells divide, one chromatid goes into one daughter cell and one goes into the
other daughter cell, making the daughter cells genetically identical
 A precise scaffolding made of protein molecules prevents the DNA from getting tangled
up into knots
 The DNA is wound around the outside of these protein molecules
 The combination of DNA and proteins is called Chromatin
 Most of the proteins are basic and are a type known as Histones
 Because they are basic, they can interact easily with DNA, which is acidic
 Chromosomes also possess two more features essential for successful nuclear division:
centromere and telomeres
 Telomeres are visible if chromosomes are stained appropriately

5.3 The cell cycle
 Mitosis is nuclear division that produces two genetically identical daughter nuclei, each
containing the same number of chromosomes as the parent nucleus
 Mitosis is part of a precisely controlled process called the cell cycle
 The cell cycle is the sequence of events that takes place between one cell division and
the next
 It has 3 phases: interphase, nuclear division and cell division
1. During interphase, the cell grows to its normal size after cell division and carries out its
normal functions
 At some point during interphase, a signal may be received that the cell should divide
again
 If this happens, the DNA in the nucleus replicates so that each chromosome consists of
two identical chromatids
 This phase of the cell cycle is called the S phase [S stands for synthesis of DNA]
 This is a relatively short phase
 The gap after cell division and before the S phase is called G1 phase (G for gap)
 The gap after the S phase and before nuclear division is called the G2 phase
 Interphase therefore consists of G1, S and G2
 During G1, cells makes the RNA, enzymes and other proteins needed for growth
 At the end of G1, the cell becomes committed to dividing or not dividing
 During G2, the cell continues to grow and the new DNA that was made during the S
phase is checked
 Any errors are usually repaired
 Preparations are also made to begin the process of division
[For example, there is a sharp increase in production of the protein tubulin which is needed to
make microtubules for the mitotic spindle]
 Nuclear division follows interphase
 It is referred to as the M phase (M for mitosis)
 Growth stops temporarily during mitosis
 After the M phase, when the nucleus is divided into two, the whole cell divides to create
two genetically identical cells
 In animals cells, cell division involves the constriction of the cytoplasm between the two
new nuclei, a process called Cytokinesis
[In plant cells it involves the formation of a new cell wall between the two new nuclei]

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