CSO Chemotherapies 2023 Exam Questions and Answers | Graded and Already passed

Bexarotene/Targretin - CORRECT ANSWER - Intrxn: grapefruit juice; limit vit A 1500 IU/day to avoid additive toxicity - SFX: elevated blood lipids Axitinib/Inlyta - CORRECT ANSWER Avoid grapefruit juice Bortezomib/Velcade - CORRECT ANSWER - Intrxn: green tea - SFX: fatigue, generalized weakness, peripheral neuropathy, n/v, D/C, decr. app, low platelets, anemia Capecitabine/Xeloda - CORRECT ANSWER Antimetabolite - SFX: n/v, D, high bili, farigue - Considerations: B6 (50-100 mg 2-3 times/d) to help w/HFS Cisplatin/Platinol - CORRECT ANSWER Alkylating Agent - SFX: n/v (severe), metallic taste changes, SIADH, renal tox., low Mg - Considerations: hydration to prevent nephrotoxicity; monitor renal fxn and lytes (Mg, Ca, Na, K) Erlotinib/Tarceva - CORRECT ANSWER - Intrxn: grapefruit juice - SFX: n/v, D, decr. app, fatigue, SOB, cough, rash Mercaptopurine/6-MP or purinethol - CORRECT ANSWER Antimetabolite SFX: n/v, mucositis, diarrhea Intrxn: avoid dairy around time of taking drug Methotrexate - CORRECT ANSWER Antimetabolite - SFX: N (severe), mucositis (severe), oral/GI ulcerations, renal toxicity - Intrxn: avoid folic acid and its derivatives, avoid alcohol (may increase hepatotoxicity) Pemetrexed/Alimta - CORRECT ANSWER Antimetabolite - SFX: n/v, D - Considerations: supplement w/folic acid (350-1000 ug) and B12 (1000 ug q 3 cycles) to prevent severe anemia starting 1 wk prior to tx and throighoit Thioguanine/6-TG - CORRECT ANSWER Antimetabolite SFX: n/v, mucositis, D Procarbazine hydrochloride/Matulane - CORRECT ANSWER - SFX: n/v (severe) - Intrxn: avoid caffeine; avoid tyramine-rich foods while taking drug and 2 weeks after (beer, red wine, sherry, distilled spirits, brewer's yeast, fava beans, raspberries, figs, dried fruits, avocados, bananas, miso, soy sauce, sauerkraut, aged and strong cheeses, anchovies, caviar, beef and chx livers, meat extracts, sausage, bologna, pepperoni, salami) Streptozocin/Zanosar - CORRECT ANSWER - SFX: n/v, nephrotoxicity - Considerations: hypoglycemia Tamoxifen/Nolvadex - CORRECT ANSWER Selective ER Modulator - SFX: n/v, D/C