Test Bank for Basic and Clinical Pharmacology 14th Edition Katzung Trevor
Table of Contents Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation .................................. 3 Chapter 2- Drug Receptors & Pharmacodynamics ..................................................
Test Bank Basic and Clinical Pharmacology 14th Edition Katzung Trevor
Table of Contents
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation .................................. 3
Chapter 2- Drug Receptors & Pharmacodynamics ............................................................................... 22
Chapter 3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action
............................................................................................................................................................. 22
Chapter 4. Drug Biotransformation ....................................................................................................... 22
Chapter 5. Pharmacogenomics ............................................................................................................ 22
Chapter 6. Introduction to Autonomic Pharmacology ............................................................................ 41
Chapter 7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs ................................................ 60
Chapter 8. Cholinoceptor-Blocking Drugs ............................................................................................. 76
Chapter 9. Adrenoceptor Agonists & Sympathomimetic Drugs\1. ......................................................... 94
Chapter 10. Adrenoceptor Antagonist Drugs ...................................................................................... 110
Chapter 11. Antihypertensive Agents.................................................................................................. 128
Chapter 12. Vasodilators & the Treatment of Angina Pectoris ............................................................ 147
Chapter 13. Drugs Used in Heart Failure ............................................................................................ 164
Chapter 14. Agents Used in Cardiac Arrhythmias ............................................................................... 180
Chapter 15. Diuretic Agents................................................................................................................ 198
Chapter 16- Histamine, Serotonin, & the Ergot Alkaloids .................................................................... 214
Chapter 17. VasoactivePeptides ........................................................................................................ 214
Chapter 18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds 223
Chapter 19-Nitric Oxide Drugs Used in Asthma .................................................................................. 229
Chapter 21. Introduction to the Pharmacology of CNS Drugs ............................................................. 229
Chapter 22-Sedative-Hypnotic Drugs ................................................................................................. 247
Chapter 23. The Alcohols ................................................................................................................... 247
Chapter 24. Antiseizure Drugs ............................................................................................................ 265
Chapter 25 -General Anesthetics........................................................................................................ 282
Chapter 26. Local Anesthetics ............................................................................................................ 282
Chapter 27. Skeletal Muscle Relaxants .............................................................................................. 300
Chapter 28. Pharmacologic Management of Parkinsonism & Other Movement Disorders .................. 317
Chapter 29. Antipsychotic Agents & Lithium ....................................................................................... 334
Chapter 30. Antidepressant Agents .................................................................................................... 352
Chapter 31- Opioid Agonists & Antagonists ........................................................................................ 371
Chapter 32. Drugs of Abuse ............................................................................................................... 371
Chapter 33. Agents Used in Cytopenias; Hematopoietic Growth Factors............................................ 387
Chapter 34. Drugs Used in Disorders of Coagulation ......................................................................... 404
Chapter 35. Agents Used in Dyslipidemia ........................................................................................... 420
Chapter 36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid
Analgesics, & Drugs Used in Gout ..................................................................................................... 438
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,Chapter 37. Hypothalamic & Pituitary Hormones ................................................................................ 455
Chapter 38. Thyroid & Antithyroid Drugs ............................................................................................ 472
Chapter 39. Adrenocorticosteroids & Adrenocortical Antagonists ....................................................... 489
Chapter 40. The Gonadal Hormones & Inhibitors ............................................................................... 507
Chapter 42. Agents That Affect Bone Mineral Homeostasis................................................................ 543
Chapter 43-Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics ...................................... 561
Chapter 44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, &
Oxazolidinones ................................................................................................................................... 561
Chapter 45. Aminoglycosides & Spectinomycin .................................................................................. 561
Chapter 46. Sulfonamides, Trimethoprim, & Quinolones ..................................................................... 561
Chapter 47. Antimycobacterial Drugs ................................................................................................. 561
Chapter 48. Antifungal Agents ............................................................................................................ 580
Chapter 49. Antiviral Agents ............................................................................................................... 598
Chapter 50- Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, &Sterilants .................... 616
Chapter 51. Clinical Use of Antimicrobial Agents ................................................................................ 616
Chapter 52. Antiprotozoal Drugs......................................................................................................... 635
Chapter 53. Clinical Pharmacology of the Antihelminthic Drugs.......................................................... 652
Chapter 54. Cancer Chemotherapy .................................................................................................... 669
Chapter 55. Immunopharmacology..................................................................................................... 688
Chapter 56-Introduction to Toxicology: Occupational & Environmental.............................................. 707
Chapter 57. Heavy Metal Intoxication & Chelators.............................................................................. 707
Chapter 58. Management of the PoisonedPatient .............................................................................. 707
Chapter 59. Special Aspects of Perinatal & Pediatric Pharmacology .................................................. 738
Chapter 60. Special Aspects of Geriatric Pharmacology..................................................................... 744
Chapter 61. Dermatologic Pharmacology ........................................................................................... 749
Chapter 62. Drugs Used in the Treatment of Gastrointestinal Diseases.............................................. 755
Chapter 63. Therapeutic & Toxic Potential of Over-the-Counter Agents ............................................. 772
Chapter 64. Dietary Supplements & Herbal Medications .................................................................... 791
Chapter 65- Rational Prescribing & Prescription Writing ..................................................................... 793
Chapter 66. Important Drug Interactions & Their Mechanisms ........................................................... 793
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,Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
1. A nurse working in radiology administers iodine to a patient who is having
a computed tomography (CT) scan. The nurse working on the oncology
unit administers chemotherapy to patients who have cancer. At the Public
Health Department, a nurse administers a measles-mumps-rubella
(MMR) vaccine to a 14-month-old child as a routine immunization. Which
branch of pharmacology best describes the actions of all three nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses
are involved with clinical pharmacology or pharmacotherapeutics, which
is a branch of pharmacology that deals with the uses of drugs to treat,
prevent, and diagnose disease. The radiology nurse is administering a
drug to help diagnose a disease. The oncology nurse is administering a
drug to help treat adisease. Pharmacoeconomics includes any costs
involved in drug therapy.
Pharmacodynamics involves how a drug affects the body
and pharmacokinetics is how the body acts on the body.
2. A physician has ordered intramuscular (IM) injections of morphine, a
narcotic, every 4 hours as needed for pain in a motor vehicle accident
victim.The nurse is aware this drug has a high abuse potential. Under
what categorywould morphine be classified?
A) Schedule I
B) Schedule II
C) Schedule III
D) Schedule IV
Ans: B
Feedback:
3|Page
, Narcotics with a high abuse potential are classified as Schedule II drugs
because of severe dependence liability. Schedule I drugs have high
abuse potential and no accepted medical use. Schedule III drugs have a
lesser abuse potential than II and an accepted medical use. Schedule IV
drugs havelow abuse potential and limited dependence liability.
3. When involved in phase III drug evaluation studies, what
responsibilities would the nurse have?
A) Working with animals who are given experimental drugs
B) Choosing appropriate patients to be involved in the drug study
C) Monitoring and observing patients closely for adverse effects
D) Conducting research to determine effectiveness of the drug
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in
which patients are asked to record any symptoms they experience while
taking thedrugs. Nurses may be responsible for helping collect and
analyze the information to be shared with the Food and Drug
Administration (FDA) butwould not conduct research independently
because nurses do not prescribe medications. Use of animals in drug
testing is done in the preclinical trials. Select patients who are involved
in phase II studies to participate in studies where the participants have
the disease the drug is intended to treat. These patients are monitored
closely for drug action and adverse effects. Phase I studies involve
healthy human volunteers who are usually paid for their participation.
Nurses may observe for adverse effects and toxicity.
4. What concept is considered when generic drugs are substituted for
brandname drugs?
A) Bioavailability
B) Critical concentration
C) Distribution
D) Half-life
Ans: A
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