ONS Chemotherapy Immunotherapy Certificate Test with Approved Answers | Latest 2023/2024
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ONS Chemotherapy Immunotherapy Certificate
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ONS Chemotherapy Immunotherapy Certificate
ONS Chemotherapy Immunotherapy Certificate Test with Approved Answers | Latest 2023/2024
3 major phases of cell division: ☑️ Interphase
Mitotic phase
Cytokinesis
3 steps of interphase: ☑️ First growth phase (G1)
Synthesis phase (S phase)
Second growth phase (G2)
4 phases of mitosis: ...
ONS Chemotherapy Immunotherapy Certificate Test with Approved Answ ers 3 major phases of cell division: ☑️ Interphase Mitotic phase Cytokinesis 3 steps of interp hase: ☑️ First growth phase (G1) Synthesis phase (S phase) Second growth phase (G2) 4 phases of mitosis: ☑️ Prophase Metaphase Anaphase Telophase Innate immunity: ☑️ Non-specific response, either: 1. Barrier (skin, mucous membranes, flora of skin/g ut) 2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages) Adaptive immunity: ☑️ Follows innate immunity if unsuccessful. Memory immunity, including: 1. Humoral immunity (production of antibodies or immunoglobulins) 2. Cell mediated immunity (dependent upon T cells) 3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses) Define mutations ☑️ Variations in the nucleotide sequence of a gene 3 main goals of treatment: ☑️ Cure Control Palliation Define neoadjuvant therapy ☑️ Treatment is given prior to surgery to shrink the tumor Define adjuvant therapy ☑️ Additional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur Define conditioning/preparative therapy ☑️ Treatments used to prepare a patient for stem cell transplantation 2 types of conditioning therapies: ☑️ Myeloablative Nonmyeloablative Define dose density ☑️ Drug dose per unit of time Define dose intensity ☑️ Amount of drug delivered over time How is relative dose intensity (RDI) calculated? ☑️ By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen How do alky lating agents work? ☑️ By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death 3 subcategories of alkylating agents: ☑️ 1. Nitrogen mustards 2. Platinum -based agents (do not possess an alkyl group but still termed alkylating agents as they work similarly) 3. Nitrosoureas Most common subcategory of alkylating agents: ☑️ Nitrogen mustards Common alkylating agents: ☑️ Cyclophosphamide (Cytox an) Ifosfamide (Ifex) Bendamustine (Treanda) Common platinum -based agents: ☑️ Cisplatin (Platinol) Carboplatin (Paraplatin) What is unique about nitrosoureas agents? ☑️ Able to cross the blood -brain barrier; can be effective in treating some brain tu mors Common nitrosoureas agents: ☑️ Carmustine (BiCNU) Lomustine (CeeNu) Streptozocin (Zanosar) Hypersensitivity can occur with late doses of: ☑️ Carboplatin These agents are typically categorized as highly emetogenic: ☑️ 1. Alkylating agents 2. Nitrosoureas Pre-administration labs for alkylating agents and nitrosoureas: ☑️ BUN Creatinine CBC w/ diff What is the medication Mesna used for? ☑️ Bladder protectant with administration of cyclophosphamide or ifosfamide Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3 -4 days following treatment ☑️ Oxaliplatin How do antimetabolites function? ☑️ By blocking DNA and RNA growth by interfering with enzymes needed for normal ce ll metabolism
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