HSCT Exam with 100% correct answers

HSCT HSCT Definition - ANSWER-Process by which abnormal hematopoiesis and/or lymphopoiesis is established by the infusion of ex-vivo PLURIPOTENT stem cells--HEMATOPOIETIC progenitor cells Chemotherapy and HSCT - ANSWER--Cancer chemotherapy agents and radiotherapy are destructive to the normal bone marrow cells *ex. CARMUSTINE will wipe out BM -Therefore, bone marrow suspension is a major limiting factor in the administration of adequate chemotherapy for CURATIVE intent What does HSCT allow for in regards to chemotherapy? - ANSWER-Allows for the administration of supralethal chemo/radiotherapy to increase the % of malignant cells destroyed while rescuing the patient from hematopoietic toxicity with the transplant HSCT new cells... - ANSWER-The new cells transplanted may allow the replacement of a n intact immune system to provide an anti-tumor effect or to provide cells that are NO longer deficient in certain vital components What are the 3 types of transplants - ANSWER-Immunologic source of stem cells : -Allogeneic -Autologous -Syngeneic Allogeneic Transplant - ANSWER--From a donor OTHER than the recipient -Provides rescue for the recipient from myeloablative therapy given for treatment of malignant disease (acute leukemia) -May help to establish a graft-versus-leukemia effect mediated by donor cell recognition and destruction/inhibition of residual host MALIGNANT cells