NURS 498 Immunity Questions With Complete Solutions.

What is the MOA of Reverse Transcriptase Inhibitors? (Zidovudine (Retrovir); emtricitabine (Emtriva)) correct answer: Block activity of the enzyme reverse transcriptase, preventing production of new viral DNA What is the MOA of protease inhibitors? (Ritonavir (Norvir); Indinavir (Crixivan)) correct answer: Inhibit the protease retroviral enzyme, preventing viral replication What is the MOA of fusion inhibitors? (Enfuvirtide (Fuzeon)) correct answer: Interfere with HIV CD4 receptor site binding and entry into cells What is the MOA of entry inhibitor: CCR5 co-receptor antagonists? (Maravicor) correct answer: Block entry into the cell What is the MOA of integrase inhibitors? (uRaltegravir (Isentress)) correct answer: work by interfering with the enzyme integrase Adverse effects of antiretroviral drugs correct answer: GI symptoms, Fatigue, osteoprorosis Chemical Categories of NSAIDs - Which meds are Salicylates? correct answer: acetylsalicylic acid (ASA) diflunisal (Apo-Diflunisal) Celecoxib (celebrex) is what chemical category of NSAIDs correct answer: Cyclooxygenase-2 (COX-2) inhibitors What meds are propionic acids correct answer: -ibuprofen (Advil, Motrin) -naproxen (Naprosyn E) -naproxen sodium (Aleve, Anaprox) What chemical category of NSAIDs do these meds belong to •diclofenac potassium (Voltaren Rapide) •diclofenac sodium (Voltaren) •sodium indomethacin (Indocin) •ketorolac tromethamine (Toradol) •Mefenamic acid (Ponstan) correct answer: Acetic acid derivatives